Tbio DRG2 Developmentally-regulated GTP-binding protein 2

Protein Summary

Description

May play a role in cell proliferation, differentiation and death. This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P55039
• B2R8G5
• Q53Y50
• Q9BWB2
• DRG-2

Gene Name

• DRG2

Ensembl ID

• ENST00000225729
• ENSP00000225729
• ENSG00000108591

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
histone modification site profile	0.87
protein domain	0.85
transcription factor binding site profile	0.78
molecular function	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.31   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.31   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0