Tchem DRD5 D(1B) dopamine receptor

Protein Summary

Description

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P21918
• B2R9S3
• Q8NEQ8

Gene Name

• DRD5

Ensembl ID

• ENST00000304374
• ENSP00000306129
• ENSG00000169676

Symbol

• DRD1B
• DRD1L2
• DBDR
• DRD1B
• DRD1L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.96
drug	0.91
ligand (chemical)	0.89
virus perturbation	0.83
molecular function	0.67

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / D(1b) Dopamine Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Dopamine Receptor / D(1b) Dopamine Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.64   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 393   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.64   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 142

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16