You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
DRD5
D(1B) dopamine receptor

Protein Summary
Description
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304374
  • ENSP00000306129
  • ENSG00000169676

Symbol
  • DRD1B
  • DRD1L2
  • DBDR
  • DRD1B
  • DRD1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
drug
0.91
ligand (chemical)
0.89
virus perturbation
0.83
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.64   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.64   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 142
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16