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Tclin
DRD3
D(3) dopamine receptor

Protein Summary
Description
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383673
  • ENSP00000373169
  • ENSG00000151577
  • ENST00000460779
  • ENSP00000419402
  • ENST00000467632
  • ENSP00000420662

Symbol
  • D3DR
  • ETM1
  • FET1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (chemical)
0.99
drug
0.98
chemical
0.87
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.15   (req: < 5)
Gene RIFs: 236   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.15   (req: >= 5)
Gene RIFs: 236   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3127
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 60
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (60)
clozapine
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chlorpromazine
Rendered image for chlorpromazine
olanzapine
Rendered image for olanzapine
amitriptyline
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thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
aripiprazole
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clemastine
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cyproheptadine
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fluphenazine
Rendered image for fluphenazine
Protein-Protein Interactions (330)
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.966
Data Source:  STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.964
Data Source:  STRINGDB
GRM2
Tchem
Family:  GPCR
Novelty:  0.00132156
Score:  0.953
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.951
Data Source:  STRINGDB
PENK
Tbio
Novelty:  0.00074167
Score:  0.95
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.95
Data Source:  STRINGDB
CNR2
Tchem
Family:  GPCR
Novelty:  0.00215391
Score:  0.95
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.948
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.948
Data Source:  STRINGDB
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Amine ligand-binding receptors (R-HSA-375280)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Dopamine receptors
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
Dopamine receptors
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (64)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
29
feeling emotionally hurt measurement
1
1
0
5.5
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
29
feeling emotionally hurt measurement
0
5.5
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dopamine receptor D3
VGNC:1797
470885
Macaque
dopamine receptor D3
100425047
Mouse
MGI:94925
13490
Rat
RGD:2521
29238
Dog
dopamine receptor D3
VGNC:40095
487984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dopamine receptor D3
Macaque
dopamine receptor D3
Mouse
Rat
Dog
dopamine receptor D3
Publication Statistics
PubMed Score 418.15
PubMed score by year
PubTator Score 372.01
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title