Protein Summary
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
- ENST00000346454
- ENSP00000278597
- ENSG00000149295
- ENST00000362072
- ENSP00000354859
- ENST00000538967
- ENSP00000438215
- ENST00000542968
- ENSP00000442172
- D2R
- D2DR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
drug | 1 | ||
ligand (chemical) | 1 | ||
molecular function | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3133.28 (req: < 5)
Gene RIFs: 821 (req: <= 3)
Antibodies: 337 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3133.28 (req: >= 5)
Gene RIFs: 821 (req: > 3)
Antibodies: 337 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 103
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3033
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 81
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (81)
Active Ligands (3033)
Protein-Protein Interactions (452)
MSRA
Family: Enzyme
Novelty: 0.00595154
p_int: 0.999998758
p_ni: 1e-8
p_wrong: 0.000001232
Score: 0.397
Data Source: BioPlex,STRINGDB
COLEC12
Novelty: 0.02882427
p_int: 0.977532225
p_ni: 0.022467763
p_wrong: 1.2e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
WDR45
Novelty: 0.0148072
p_int: 0.958364201
p_ni: 0.040451262
p_wrong: 0.001184537
Score: 0.199
Data Source: BioPlex,STRINGDB
NDFIP1
Novelty: 0.04496467
p_int: 0.804954611
p_ni: 0.195044898
p_wrong: 4.91e-7
Score: 0.193
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (39)
Reactome (8)
KEGG (8)
PathwayCommons (15)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Dopamine receptors | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Dopamine receptors | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (123)
Functions (9)
Components (20)
Processes (94)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (31)
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 14 | 12 | 1 | 97.2 | |||||
neuroticism measurement | 8 | 24 | 18 | 6.8 | 94.9 | ||||
wellbeing measurement | 4 | 11 | 17 | 94.1 | |||||
depressive symptom measurement | 2 | 7 | 7 | 92.9 | |||||
alcohol consumption measurement | 7 | 8 | 8 | 1.1 | 90.9 | ||||
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
12 | 1 | 97.2 | |||||
neuroticism measurement | 18 | 6.8 | 94.9 | ||||
wellbeing measurement | 17 | 94.1 | |||||
depressive symptom measurement | 7 | 92.9 | |||||
alcohol consumption measurement | 8 | 1.1 | 90.9 | ||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dopamine receptor D2 | VGNC:3283 | 451553 | |||||
Macaque | dopamine receptor D2 | 694181 | ||||||
Mouse | MGI:94924 | 13489 | ||||||
Rat | RGD:2520 | 24318 | ||||||
Dog | dopamine receptor D2 | VGNC:40094 | 403701 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dopamine receptor D2 | |||||
Macaque | dopamine receptor D2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dopamine receptor D2 | |||||
Publication Statistics
PubMed Score 3133.28
PubMed score by year
PubTator Score 2969.27
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (1127)
GeneRif Annotations (821)
Items per page:
0 of 0
PMID | Year | Title |
|---|