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Tclin
DRD2
D(2) dopamine receptor

Protein Summary
Description
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346454
  • ENSP00000278597
  • ENSG00000149295
  • ENST00000362072
  • ENSP00000354859
  • ENST00000538967
  • ENSP00000438215
  • ENST00000542968
  • ENSP00000442172

Symbol
  • D2R
  • D2DR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
drug
1
ligand (chemical)
1
molecular function
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3133.28   (req: < 5)
Gene RIFs: 821   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3133.28   (req: >= 5)
Gene RIFs: 821   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 103
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3033
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 81
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (81)
clozapine
Rendered image for clozapine
chlorpromazine
Rendered image for chlorpromazine
olanzapine
Rendered image for olanzapine
thioridazine
Rendered image for thioridazine
risperidone
Rendered image for risperidone
aripiprazole
Rendered image for aripiprazole
clemastine
Rendered image for clemastine
cyproheptadine
Rendered image for cyproheptadine
fluphenazine
Rendered image for fluphenazine
lisuride
Rendered image for lisuride
Protein-Protein Interactions (452)
MSRA
Tbio
Family:  Enzyme
Novelty:  0.00595154
p_int:  0.999998758
p_ni:  1e-8
p_wrong:  0.000001232
Score:  0.397
Data Source:  BioPlex,STRINGDB
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.977532225
p_ni:  0.022467763
p_wrong:  1.2e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
WDR45
Tbio
Novelty:  0.0148072
p_int:  0.958364201
p_ni:  0.040451262
p_wrong:  0.001184537
Score:  0.199
Data Source:  BioPlex,STRINGDB
NDFIP1
Tbio
Novelty:  0.04496467
p_int:  0.804954611
p_ni:  0.195044898
p_wrong:  4.91e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
SLC6A3
Tclin
Family:  Transporter
Novelty:  0.00017601
Score:  0.99
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.984
Data Source:  STRINGDB
NCS1
Tbio
Novelty:  0.0051468
Score:  0.977
Data Source:  STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.974
Data Source:  STRINGDB
PENK
Tbio
Novelty:  0.00074167
Score:  0.969
Data Source:  STRINGDB
PDYN
Tbio
Novelty:  0.00039564
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Amine ligand-binding receptors (R-HSA-375280)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Dopamine receptors
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
Dopamine receptors
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (123)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
14
12
1
97.2
neuroticism measurement
8
24
18
6.8
94.9
wellbeing measurement
4
11
17
94.1
depressive symptom measurement
2
7
7
92.9
alcohol consumption measurement
7
8
8
1.1
90.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
12
1
97.2
neuroticism measurement
18
6.8
94.9
wellbeing measurement
17
94.1
depressive symptom measurement
7
92.9
alcohol consumption measurement
8
1.1
90.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dopamine receptor D2
VGNC:3283
451553
Macaque
dopamine receptor D2
694181
Mouse
MGI:94924
13489
Rat
RGD:2520
24318
Dog
dopamine receptor D2
VGNC:40094
403701
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dopamine receptor D2
Macaque
dopamine receptor D2
Mouse
Rat
Dog
dopamine receptor D2
Publication Statistics
PubMed Score 3133.28
PubMed score by year
PubTator Score 2969.27
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title