Protein Summary
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
- ENST00000393752
- ENSP00000377353
- ENSG00000184845
- DADR
- DRD1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
drug | 1 | ||
co-expressed gene | 0.97 | ||
chemical | 0.96 | ||
ligand (chemical) | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 686.06 (req: < 5)
Gene RIFs: 187 (req: <= 3)
Antibodies: 613 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 686.06 (req: >= 5)
Gene RIFs: 187 (req: > 3)
Antibodies: 613 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 547
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 31