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Tclin
DRD1
D(1A) dopamine receptor

Protein Summary
Description
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393752
  • ENSP00000377353
  • ENSG00000184845

Symbol
  • DADR
  • DRD1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug
1
co-expressed gene
0.97
chemical
0.96
ligand (chemical)
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 686.06   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 613   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 686.06   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 613   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 547
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 31