Protein Summary
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
- ENST00000393752
- ENSP00000377353
- ENSG00000184845
- DADR
- DRD1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
drug | 1 | ||
co-expressed gene | 0.97 | ||
chemical | 0.96 | ||
ligand (chemical) | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 500.2 (req: < 5)
Gene RIFs: 187 (req: <= 3)
Antibodies: 613 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 500.2 (req: >= 5)
Gene RIFs: 187 (req: > 3)
Antibodies: 613 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 519
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 31
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (31)
Active Ligands (519)
Protein-Protein Interactions (276)
Nearest Tclin Targets
Pathways (40)
Reactome (8)
KEGG (10)
PathwayCommons (16)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Dopamine receptors | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Dopamine receptors | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (65)
Functions (4)
Components (10)
Processes (51)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (0)
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IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | dopamine receptor D1 | 697796 | ||||||
Mouse | MGI:99578 | 13488 | ||||||
Rat | RGD:2518 | 24316 | ||||||
Dog | dopamine receptor D1 | VGNC:40093 | 489110 | |||||
Cow | dopamine receptor D1 | VGNC:28207 | 281125 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | dopamine receptor D1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dopamine receptor D1 | |||||
Cow | dopamine receptor D1 | |||||
Publication Statistics
PubMed Score 500.20
PubMed score by year
PubTator Score 587.36
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (270)
GeneRif Annotations (187)
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