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Tdark
DRC7
Dynein regulatory complex subunit 7

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336825
  • ENSP00000338938
  • ENSG00000159625
  • ENST00000360716
  • ENSP00000353942
  • ENST00000394337
  • ENSP00000377869

Symbol
  • C16orf50
  • CCDC135
  • FAP50
  • CFAP50
  • CCDC135
  • C16orf50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.57
virus perturbation
0.5
cellular component
0.46
protein complex
0.4
transcription factor
0.37


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
IQCD
Tbio
Novelty:  0.21789956
Score:  0.753
Data Source:  STRINGDB
ANKDD1A
Tdark
Novelty:  1.522813
Score:  0.75
Data Source:  STRINGDB
GAS8
Tbio
Novelty:  0.03540885
Score:  0.719
Data Source:  STRINGDB
IQCA1
Tdark
Novelty:  0.33986781
Score:  0.702
Data Source:  STRINGDB
TAGAP
Tbio
Family:  Enzyme
Novelty:  0.04450409
Score:  0.688
Data Source:  STRINGDB
SOWAHD
Tdark
Novelty:  6.91525424
Score:  0.682
Data Source:  STRINGDB
TCTE1
Tbio
Novelty:  0.11008102
Score:  0.68
Data Source:  STRINGDB
ARHGAP45
Tbio
Novelty:  0.13518861
Score:  0.653
Data Source:  STRINGDB
MDN1
Tdark
Novelty:  0.02111664
Score:  0.648
Data Source:  STRINGDB
SAMD10
Tdark
Novelty:  2.02197004
Score:  0.648
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
61.8
high density lipoprotein cholesterol measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
61.8
high density lipoprotein cholesterol measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein regulatory complex subunit 7
VGNC:13700
454123
Macaque
dynein regulatory complex subunit 7
711779
Mouse
MGI:2685616
330830
Rat
RGD:1565601
291853
Dog
dynein regulatory complex subunit 7
VGNC:40092
487260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein regulatory complex subunit 7
Macaque
dynein regulatory complex subunit 7
Mouse
Rat
Dog
dynein regulatory complex subunit 7
Publication Statistics
PubMed Score 2.93
PubMed score by year
PubTator Score 0.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title