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Tdark
DRC3
Dynein regulatory complex subunit 3

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313838
  • ENSP00000326870
  • ENSG00000171962
  • ENST00000399182
  • ENSP00000382136
  • ENST00000399187
  • ENSP00000382140
  • ENST00000584166
  • ENSP00000462661

Symbol
  • LRRC48
  • LRRC48
  • CFAP134
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.74   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.74   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.999999654
p_ni:  3.46e-7
Data Source:  BioPlex
CCDC186
Tdark
Novelty:  0.44973807
p_int:  0.999359533
p_ni:  0.000639385
p_wrong:  0.000001082
Data Source:  BioPlex
MAP7D1
Tdark
Novelty:  0.43190333
p_int:  0.993149545
p_ni:  0.006850455
Data Source:  BioPlex
ALMS1
Tbio
Novelty:  0.00694228
p_int:  0.988809815
p_ni:  0.011190185
Data Source:  BioPlex
SMG8
Tdark
Novelty:  0.18080965
p_int:  0.979689929
p_ni:  0.020309838
p_wrong:  2.34e-7
Data Source:  BioPlex
BRIP1
Tbio
Novelty:  0.03886334
p_int:  0.943995827
p_ni:  0.055920826
p_wrong:  0.000083347
Data Source:  BioPlex
MARCH7
Tbio
Family:  Enzyme
Novelty:  0.03358004
p_int:  0.933927804
p_ni:  0.066072189
p_wrong:  7e-9
Data Source:  BioPlex
PRKD2
Tchem
Family:  Kinase
Novelty:  0.03143723
p_int:  0.929821754
p_ni:  0.041997085
p_wrong:  0.028181162
Data Source:  BioPlex
HAUS7
Tbio
Novelty:  1.11657571
p_int:  0.929297665
p_ni:  0.032657584
p_wrong:  0.038044751
Data Source:  BioPlex
ZNF281
Tbio
Family:  TF
Novelty:  0.08218798
p_int:  0.91778899
p_ni:  0.08221101
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
93.9
waist-hip ratio
2
3
3
78.6
BMI-adjusted waist-hip ratio
2
3
3
75.8
bone density
1
4
4
68.1
6
4
1
1.1
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
93.9
waist-hip ratio
3
78.6
BMI-adjusted waist-hip ratio
3
75.8
bone density
4
68.1
1
1.1
57.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein regulatory complex subunit 3
VGNC:12149
743689
Macaque
dynein regulatory complex subunit 3
699590
Mouse
MGI:1921915
74665
Rat
RGD:1309150
287371
Dog
dynein regulatory complex subunit 3
VGNC:53350
479525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein regulatory complex subunit 3
Macaque
dynein regulatory complex subunit 3
Mouse
Rat
Dog
dynein regulatory complex subunit 3
Publication Statistics
PubMed Score 0.74
PubMed score by year
PubTator Score 3.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title