Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

DQX1

Ensembl ID

ENST00000393951
ENSP00000377523
ENSG00000144045
ENST00000404568
ENSP00000384621

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99

protein domain	0.73

tissue sample	0.71

gene perturbation	0.68

disease perturbation	0.62

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.47 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 118 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.47 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 118 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (226)

Explore Interacting Targets

1 – 10 of 226

See Interactions on String-DB

MYO9A

Tbio

Novelty: 0.09467086

p_int: 0.994981633

p_ni: 0.005018366

p_wrong: 2e-9

Score: 0.183

Data Source: BioPlex,STRINGDB

LRIF1

Tdark

Novelty: 0.26861958

p_int: 0.994702615

p_ni: 0.005297385

Score: 0.161

Data Source: BioPlex,STRINGDB

MYO5C

Tbio

Novelty: 0.05680943

p_int: 0.991679477

p_ni: 0.008320523

Data Source: BioPlex

PSMG4

Tdark

Novelty: 0.05339077

p_int: 0.987788866

p_ni: 0.012209871

p_wrong: 0.000001263

Data Source: BioPlex

MYO9B

Tbio

Novelty: 0.0164265

p_int: 0.981764403

p_ni: 0.018235597

Score: 0.186

Data Source: BioPlex,STRINGDB

KIF1A

Tbio

Novelty: 0.00505209

p_int: 0.948897139

p_ni: 0.051091485

p_wrong: 0.000011376

Score: 0.248

Data Source: BioPlex,STRINGDB

APPBP2

Tbio

Novelty: 0.14742368

p_int: 0.939325256

p_ni: 0.060672092

p_wrong: 0.000002652

Data Source: BioPlex

FBXO30

Tdark

Novelty: 0.60394319

p_int: 0.930193129

p_ni: 0.069806871

Score: 0.189

Data Source: BioPlex,STRINGDB

PER1

Tbio

Novelty: 0.01290576

p_int: 0.91645322

p_ni: 0.083542795

p_wrong: 0.000003985

Data Source: BioPlex

PEAK1

Tchem

Family: Kinase

Novelty: 0.02919858

p_int: 0.893545505

p_ni: 0.106454495

Score: 0.179

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
ATP-dependent 3'-5' RNA helicase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

RNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (3)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
platelet count	EFO_0004309	1	1	1	64.9

body height	EFO_0004339	1	1	1	59.9

platelet crit	EFO_0007985	1	1	1	59

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
platelet count	EFO_0004309	1	64.9

body height	EFO_0004339	1	59.9

platelet crit	EFO_0007985	1	59

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

Find Similar Targets

No Header	No Header
Alternative splicing

ATP-binding

Complete proteome

Helicase

Hydrolase

Nucleotide-binding

Nucleus

Reference proteome

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID
Chimp	DEAQ-box RNA dependent ATPase 1	VGNC:226	470409

Macaque	DEAQ-box RNA dependent ATPase 1		709749

Mouse	DEAQ RNA-dependent ATPase	MGI:2136388	93838

Rat	DEAQ box RNA-dependent ATPase 1	RGD:1591766	680434

Dog	DEAQ-box RNA dependent ATPase 1	VGNC:40086	475784

Species	Name	OMA	EggNOG	Inparanoid
Chimp	DEAQ-box RNA dependent ATPase 1

Macaque	DEAQ-box RNA dependent ATPase 1

Mouse	DEAQ RNA-dependent ATPase

Rat	DEAQ box RNA-dependent ATPase 1

Dog	DEAQ-box RNA dependent ATPase 1

Publication Statistics

PubMed Score 2.47

PubMed score by year

PubTator Score 1.25

PubTator score by year

Related Publications

Text Mined References (4)

Items per page:

0 of 0

PMID	Year	Title