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Tbio
DPYSL3
Dihydropyrimidinase-related protein 3

Protein Summary
Description
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343218
  • ENSP00000343690
  • ENSG00000113657
  • ENST00000398514
  • ENSP00000381526

Symbol
  • CRMP4
  • DRP3
  • ULIP
  • ULIP1
  • DRP3
  • ULIP
  • CRMP4
  • DRP-3
  • LCRMP
  • CRMP-4
  • ULIP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
PubMedID
0.92
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83
disease perturbation
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.82   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.82   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
CRMP1
Tbio
Family:  Enzyme
Novelty:  0.01998451
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.989
Data Source:  BioPlex,STRINGDB
DPYSL2
Tbio
Family:  Enzyme
Novelty:  0.00374969
p_int:  0.999999964
p_ni:  3.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
DPYSL5
Tbio
Family:  Enzyme
Novelty:  0.0052536
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.985
Data Source:  BioPlex,STRINGDB
DPYSL4
Tbio
Family:  Enzyme
Novelty:  0.0449179
p_int:  0.999998162
p_ni:  0.000001838
Score:  0.957
Data Source:  BioPlex,STRINGDB
DPYS
Tbio
Family:  Enzyme
Novelty:  0.01272377
p_int:  0.999998114
p_ni:  0.000001886
Score:  0.865
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999923493
p_ni:  0.000076507
Data Source:  BioPlex
KIZ
Tbio
Novelty:  0.0644373
p_int:  0.999898859
p_ni:  0.000101141
Score:  0.188
Data Source:  BioPlex,STRINGDB
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999653497
p_ni:  0.000346503
Score:  0.246
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999574664
p_ni:  0.000425335
Score:  0.196
Data Source:  BioPlex,STRINGDB
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999169204
p_ni:  0.000830796
Score:  0.229
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
Semaphorin interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
WormBase
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
77.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase like 3
VGNC:3970
462171
Macaque
dihydropyrimidinase like 3
708425
Mouse
MGI:1349762
22240
Rat
RGD:2410
25418
Dog
dihydropyrimidinase like 3
VGNC:40084
487204
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase like 3
Macaque
dihydropyrimidinase like 3
Mouse
Rat
Dog
dihydropyrimidinase like 3
Publication Statistics
PubMed Score 93.82
PubMed score by year
PubTator Score 43.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title