You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DPYSL2
Dihydropyrimidinase-related protein 2

Protein Summary
Description
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311151
  • ENSP00000309539
  • ENSG00000092964
  • ENST00000523027
  • ENSP00000431117

Symbol
  • CRMP2
  • ULIP2
  • DRP2
  • N2A3
  • CRMP2
  • DRP-2
  • ULIP2
  • CRMP-2
  • DHPRP2
  • ULIP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.96
PubMedID
0.94
virus perturbation
0.94
kinase perturbation
0.93
cellular component
0.85


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.39   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 534   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.39   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 534   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0