Protein Summary
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
- ENST00000351513
- ENSP00000276651
- ENSG00000147647
- DHP
- DHPase
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.84 | ||
gene perturbation | 0.77 | ||
virus perturbation | 0.72 | ||
cell line | 0.68 | ||
PubMedID | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.65 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 285 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.65 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 285 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (70)
DPYSL3
Family: Enzyme
Novelty: 0.01284077
p_int: 0.999998114
p_ni: 0.000001886
Score: 0.865
Data Source: BioPlex,STRINGDB
DPYSL2
Family: Enzyme
Novelty: 0.00374969
p_int: 0.999950103
p_ni: 0.000049897
Score: 0.853
Data Source: BioPlex,STRINGDB
DPYSL5
Family: Enzyme
Novelty: 0.0052536
p_int: 0.999602053
p_ni: 0.000397947
Score: 0.876
Data Source: BioPlex,STRINGDB
DPYSL4
Family: Enzyme
Novelty: 0.0449179
p_int: 0.807169763
p_ni: 0.192419345
p_wrong: 0.000410892
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (19)
Reactome (4)
KEGG (5)
PathwayCommons (6)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Pyrimidine catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Pyrimidine catabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (6)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
salivary metabolite measurement | 1 | 1 | 1 | 84.6 | |||||
metabolite measurement | 1 | 1 | 1 | 77.7 | |||||
1 | 1 | 0 | 1.4 | 67.7 | |||||
disease progression measurement | 1 | 1 | 0 | 4.7 | 48.5 | ||||
irritability measurement | 1 | 1 | 0 | 5.5 | 2.5 | ||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
salivary metabolite measurement | 1 | 84.6 | |||||
metabolite measurement | 1 | 77.7 | |||||
0 | 1.4 | 67.7 | |||||
disease progression measurement | 0 | 4.7 | 48.5 | ||||
irritability measurement | 0 | 5.5 | 2.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dihydropyrimidinase | VGNC:887 | 464330 | |||||
Macaque | dihydropyrimidinase | 695342 | ||||||
Mouse | MGI:1928679 | 64705 | ||||||
Rat | RGD:68376 | 65135 | ||||||
Dog | dihydropyrimidinase | VGNC:40082 | 100856067 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dihydropyrimidinase | |||||
Macaque | dihydropyrimidinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | dihydropyrimidinase | |||||
Publication Statistics
PubMed Score 74.65
PubMed score by year
PubTator Score 202.53
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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