Protein Summary
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
- ENST00000351513
- ENSP00000276651
- ENSG00000147647
- DHP
- DHPase
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.84 | ||
gene perturbation | 0.77 | ||
virus perturbation | 0.72 | ||
cell line | 0.68 | ||
PubMedID | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.65 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 285 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.65 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 285 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (70)
DPYSL3
Family: Enzyme
Novelty: 0.01284077
p_int: 0.999998114
p_ni: 0.000001886
Score: 0.865
Data Source: BioPlex,STRINGDB
DPYSL2
Family: Enzyme
Novelty: 0.00374969
p_int: 0.999950103
p_ni: 0.000049897
Score: 0.853
Data Source: BioPlex,STRINGDB
DPYSL5
Family: Enzyme
Novelty: 0.0052536
p_int: 0.999602053
p_ni: 0.000397947
Score: 0.876
Data Source: BioPlex,STRINGDB
DPYSL4
Family: Enzyme
Novelty: 0.0449179
p_int: 0.807169763
p_ni: 0.192419345
p_wrong: 0.000410892
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (19)
Reactome (4)
KEGG (5)
PathwayCommons (6)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Pyrimidine catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Pyrimidine catabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (6)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
salivary metabolite measurement | 1 | 1 | 1 | 84.6 | |||||
metabolite measurement | 1 | 1 | 1 | 77.7 | |||||
1 | 1 | 0 | 1.4 | 67.7 | |||||
disease progression measurement | 1 | 1 | 0 | 4.7 | 48.5 | ||||
irritability measurement | 1 | 1 | 0 | 5.5 | 2.5 | ||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
salivary metabolite measurement | 1 | 84.6 | |||||
metabolite measurement | 1 | 77.7 | |||||
0 | 1.4 | 67.7 | |||||
disease progression measurement | 0 | 4.7 | 48.5 | ||||
irritability measurement | 0 | 5.5 | 2.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dihydropyrimidinase | VGNC:887 | 464330 | |||||
Macaque | dihydropyrimidinase | 695342 | ||||||
Mouse | MGI:1928679 | 64705 | ||||||
Rat | RGD:68376 | 65135 | ||||||
Dog | dihydropyrimidinase | VGNC:40082 | 100856067 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | dihydropyrimidinase | |||||
Macaque | dihydropyrimidinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | dihydropyrimidinase | |||||
Publication Statistics
PubMed Score 74.65
PubMed score by year
PubTator Score 202.53
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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