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Tbio
DPY30
Protein dpy-30 homolog

Protein Summary
Description
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295066
  • ENSP00000295066
  • ENSG00000162961
  • ENST00000342166
  • ENSP00000345837

Symbol
  • Cps25
  • Saf19
  • HDPY-30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
disease perturbation
0.83
histone modification site profile
0.79
small molecule perturbation
0.71
tissue sample
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.57   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.57   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.999
Data Source:  STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.998
Data Source:  STRINGDB
SETD1B
Tbio
Family:  Epigenetic
Novelty:  0.03331663
Score:  0.997
Data Source:  STRINGDB
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
Score:  0.996
Data Source:  STRINGDB
WDR82
Tbio
Novelty:  0.04679153
Score:  0.996
Data Source:  STRINGDB
WDR5
Tchem
Novelty:  0.0059945
Score:  0.99
Data Source:  STRINGDB
KMT2C
Tbio
Family:  Epigenetic
Novelty:  0.00689437
Score:  0.986
Data Source:  STRINGDB
CXXC1
Tbio
Family:  Epigenetic
Novelty:  0.01019251
Score:  0.982
Data Source:  STRINGDB
PAXIP1
Tbio
Novelty:  0.01728724
Score:  0.98
Data Source:  STRINGDB
KMT2D
Tbio
Family:  Epigenetic
Novelty:  0.00380525
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
PKMTs methylate histone lysines
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
77.7
1
1
1
77.4
interleukin 18 measurement
1
1
1
24.2
interleukin 1 receptor antagonist measurement
1
1
1
24.2
interleukin-1 beta measurement
1
1
1
24.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
77.7
1
77.4
interleukin 18 measurement
1
24.2
interleukin 1 receptor antagonist measurement
1
24.2
interleukin-1 beta measurement
1
24.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dpy-30, histone methyltransferase complex regulatory subunit
VGNC:220
743512
Macaque
dpy-30, histone methyltransferase complex regulatory subunit
706155
Mouse
MGI:1913560
66310
Rat
RGD:708575
286897
Dog
dpy-30, histone methyltransferase complex regulatory subunit
VGNC:49106
475715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dpy-30, histone methyltransferase complex regulatory subunit
Macaque
dpy-30, histone methyltransferase complex regulatory subunit
Mouse
Rat
Dog
dpy-30, histone methyltransferase complex regulatory subunit
Publication Statistics
PubMed Score 35.57
PubMed score by year
PubTator Score 18.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title