You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
DPY19L4
Probable C-mannosyltransferase DPY19L4

Protein Summary
Description
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000414645
  • ENSP00000389630
  • ENSG00000156162
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.78
cell type or tissue
0.71
microRNA
0.64
cell line
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
SLC10A7
Tbio
Family:  Transporter
Novelty:  0.15556211
p_int:  0.9999678
p_ni:  0.000032199
Score:  0.163
Data Source:  BioPlex,STRINGDB
NAT8B
Tbio
Family:  Enzyme
p_int:  0.99992353
p_ni:  0.000076333
p_wrong:  1.37e-7
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.999622689
p_ni:  0.00037656
p_wrong:  7.51e-7
Data Source:  BioPlex
C15orf32
Tdark
Novelty:  8.4527027
p_int:  0.998961928
p_ni:  0.001037991
p_wrong:  8.1e-8
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.998329274
p_ni:  0.001670691
p_wrong:  3.4e-8
Data Source:  BioPlex
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.998326938
p_ni:  0.001673058
p_wrong:  3e-9
Data Source:  BioPlex
GP9
Tbio
Novelty:  0.00365769
p_int:  0.998260748
p_ni:  0.00173631
p_wrong:  0.000002942
Data Source:  BioPlex
OR2G6
Tdark
Family:  oGPCR
p_int:  0.997073964
p_ni:  0.002922881
p_wrong:  0.000003155
Data Source:  BioPlex
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.994043853
p_ni:  0.004559844
p_wrong:  0.001396303
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.992742107
p_ni:  0.006759009
p_wrong:  0.000498885
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
50.6
urate measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
50.6
urate measurement
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dpy-19 like 4
VGNC:6682
100614971
Macaque
dpy-19 like 4
700921
Mouse
MGI:2685869
381510
Rat
RGD:1305828
297824
Dog
dpy-19 like 4
VGNC:49601
611671
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dpy-19 like 4
Macaque
dpy-19 like 4
Mouse
Rat
Dog
dpy-19 like 4
Publication Statistics
PubMed Score 0.56
PubMed score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title