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Tbio
DPY19L3
Probable C-mannosyltransferase DPY19L3

Protein Summary
Description
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342179
  • ENSP00000344937
  • ENSG00000178904
  • ENST00000392250
  • ENSP00000376081
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
microRNA
0.68
virus perturbation
0.68
cell line
0.62
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.58   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.58   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
C8B
Tbio
Novelty:  0.00873524
p_int:  0.999999989
p_ni:  1.1e-8
Data Source:  BioPlex
SPON1
Tbio
Novelty:  0.01071398
p_int:  0.999999443
p_ni:  5.57e-7
Data Source:  BioPlex
THBS2
Tbio
Novelty:  0.00310724
p_int:  0.999994868
p_ni:  0.000004949
p_wrong:  1.83e-7
Score:  0.194
Data Source:  BioPlex,STRINGDB
RSPO3
Tbio
Novelty:  0.02321039
p_int:  0.999990664
p_ni:  0.000009324
p_wrong:  1.2e-8
Score:  0.551
Data Source:  BioPlex,STRINGDB
PAPLN
Tbio
Novelty:  0.06871524
p_int:  0.999982881
p_ni:  0.000013406
p_wrong:  0.000003713
Score:  0.255
Data Source:  BioPlex,STRINGDB
C6
Tbio
Novelty:  0.0132784
p_int:  0.999965824
p_ni:  0.000034167
p_wrong:  9e-9
Score:  0.29
Data Source:  BioPlex,STRINGDB
CFP
Tbio
Novelty:  0.00063251
p_int:  0.999954063
p_ni:  0.000045924
p_wrong:  1.4e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
PPY
Tbio
Novelty:  0.00060933
p_int:  0.999946379
p_ni:  0.000050493
p_wrong:  0.000003128
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999893909
p_ni:  0.000105041
p_wrong:  0.00000105
Data Source:  BioPlex
DDRGK1
Tbio
Novelty:  0.10774064
p_int:  0.999560658
p_ni:  0.000143839
p_wrong:  0.000295503
Score:  0.211
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
4
89.6
mean platelet volume
3
1
3
82.4
mean corpuscular volume
1
2
2
81
mean reticulocyte volume
1
2
2
74
reticulocyte measurement
1
1
1
71.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
89.6
mean platelet volume
3
82.4
mean corpuscular volume
2
81
mean reticulocyte volume
2
74
reticulocyte measurement
1
71.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dpy-19 like C-mannosyltransferase 3
455919
Macaque
dpy-19 like C-mannosyltransferase 3
702159
Mouse
MGI:2443952
233115
Rat
RGD:1308334
308519
Dog
dpy-19 like C-mannosyltransferase 3
VGNC:49600
611998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dpy-19 like C-mannosyltransferase 3
Macaque
dpy-19 like C-mannosyltransferase 3
Mouse
Rat
Dog
dpy-19 like C-mannosyltransferase 3
Publication Statistics
PubMed Score 3.58
PubMed score by year
PubTator Score 1.73
PubTator score by year
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Related Publications
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PMID
Year
Title