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Tbio
DPY19L2
Probable C-mannosyltransferase DPY19L2

Protein Summary
Description
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation. The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324472
  • ENSP00000315988
  • ENSG00000177990

Symbol
  • SPGF9
  • SPATA34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
histone modification site profile
0.71
cellular component
0.63
tissue sample
0.55
virus perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.21   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.21   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
GUK1
Tbio
Family:  Kinase
Novelty:  0.00475753
p_int:  0.972705414
p_ni:  0.027294586
Score:  0.68
Data Source:  BioPlex,STRINGDB
SPATA16
Tbio
Novelty:  0.05703517
Score:  0.867
Data Source:  STRINGDB
SPACA1
Tbio
Novelty:  0.07415851
Score:  0.766
Data Source:  STRINGDB
SUN5
Tbio
Novelty:  0.04753659
Score:  0.763
Data Source:  STRINGDB
PICK1
Tbio
Novelty:  0.0058265
Score:  0.669
Data Source:  STRINGDB
AURKC
Tchem
Family:  Kinase
Novelty:  0.00950433
Score:  0.589
Data Source:  STRINGDB
GOPC
Tchem
Novelty:  0.01110168
Score:  0.582
Data Source:  STRINGDB
ZPBP
Tbio
Novelty:  0.02857503
Score:  0.564
Data Source:  STRINGDB
GBA2
Tchem
Family:  Enzyme
Novelty:  0.01340895
Score:  0.56
Data Source:  STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
Score:  0.535
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
1
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dpy-19 like 2
107967487
Mouse
MGI:2444662
320752
Dog
dpy-19 like 2
475282
Cow
dpy-19 like 2
524676
Pig
dpy-19 like 2
100524658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dpy-19 like 2
Mouse
Dog
dpy-19 like 2
Cow
dpy-19 like 2
Pig
dpy-19 like 2
Publication Statistics
PubMed Score 41.21
PubMed score by year
PubTator Score 25.40
PubTator score by year
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Related Publications
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PMID
Year
Title