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Tbio
DPPA3
Developmental pluripotency-associated protein 3

Protein Summary
Description
Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345088
  • ENSP00000339250
  • ENSG00000187569

Symbol
  • STELLAR
  • Pgc7
  • STELLA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.7
cell type or tissue
0.61
PubMedID
0.6
transcription factor binding site profile
0.42
cellular component
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.31   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.31   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
UHRF2
Tbio
Family:  Epigenetic
Novelty:  0.02205863
p_int:  0.999999997
p_ni:  3e-9
Score:  0.281
Data Source:  BioPlex,STRINGDB
UHRF1
Tbio
Family:  Epigenetic
Novelty:  0.00482565
p_int:  0.99999981
p_ni:  1.88e-7
p_wrong:  2e-9
Score:  0.43
Data Source:  BioPlex,STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
p_int:  0.999998686
p_ni:  0.000001313
p_wrong:  1e-9
Data Source:  BioPlex
TBKBP1
Tbio
Family:  Enzyme
Novelty:  0.11778482
p_int:  0.999989585
p_ni:  0.000010351
p_wrong:  6.4e-8
Data Source:  BioPlex
GREB1
Tbio
Novelty:  0.01644388
p_int:  0.998535195
p_ni:  0.001463988
p_wrong:  8.17e-7
Data Source:  BioPlex
STX8
Tbio
Novelty:  0.01083752
p_int:  0.923657251
p_ni:  0.076337903
p_wrong:  0.000004846
Data Source:  BioPlex
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.897194317
p_ni:  0.102805683
Data Source:  BioPlex
BRCA2
Tbio
Novelty:  0.0002217
p_int:  0.883728877
p_ni:  0.116271123
Data Source:  BioPlex
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.832307332
p_ni:  0.15700922
p_wrong:  0.010683448
Data Source:  BioPlex
TET3
Tbio
Family:  Enzyme
Novelty:  0.00557444
Score:  0.801
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
7.1
high density lipoprotein cholesterol measurement
1
1
1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
7.1
high density lipoprotein cholesterol measurement
1
1.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 28.31
PubMed score by year
PubTator Score 157.49
PubTator score by year
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Related Publications
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PMID
Year
Title