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Tchem
DPP9
Dipeptidyl peptidase 9

Protein Summary
Description
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262960
  • ENSP00000262960
  • ENSG00000142002
  • ENST00000594671
  • ENSP00000472224
  • ENST00000598800
  • ENSP00000469603

Symbol
  • DPRP2
  • DP9
  • DPLP9
  • DPRP2
  • DPP IX
  • DPRP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
histone modification site profile
0.83
tissue sample
0.64
cell type or tissue
0.61
tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.51   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.51   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 207
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4