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Tchem
DPP8
Dipeptidyl peptidase 8

Protein Summary
Description
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300141
  • ENSP00000300141
  • ENSG00000074603
  • ENST00000321147
  • ENSP00000318111
  • ENST00000341861
  • ENSP00000339208
  • ENST00000358939
  • ENSP00000351817
  • ENST00000559233
  • ENSP00000453954

Symbol
  • DPRP1
  • DP8
  • DPRP1
  • DPRP-1
  • MST097
  • MSTP097
  • MSTP135
  • MSTP141
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
transcription factor binding site profile
0.87
transcription factor
0.66
histone modification site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.32   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.32   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 274
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4