You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
DPP4
Dipeptidyl peptidase 4

Protein Summary
Description
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth facto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360534
  • ENSP00000353731
  • ENSG00000197635

Symbol
  • ADCP2
  • CD26
  • CD26
  • ADABP
  • ADCP2
  • DPPIV
  • TP103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
drug
1
PubMedID
0.99
cellular component
0.98
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7437.02   (req: < 5)
Gene RIFs: 359   (req: <= 3)
Antibodies: 1632   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7437.02   (req: >= 5)
Gene RIFs: 359   (req: > 3)
Antibodies: 1632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3393
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12