Protein Summary
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth facto ...more
- ENST00000360534
- ENSP00000353731
- ENSG00000197635
- ADCP2
- CD26
- CD26
- ADABP
- ADCP2
- DPPIV
- TP103
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
drug | 1 | ||
PubMedID | 0.99 | ||
cellular component | 0.98 | ||
transcription factor perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6514.84 (req: < 5)
Gene RIFs: 359 (req: <= 3)
Antibodies: 1632 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6514.84 (req: >= 5)
Gene RIFs: 359 (req: > 3)
Antibodies: 1632 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3329
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 12
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (12)
Active Ligands (3329)
Protein-Protein Interactions (177)
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Incretin synthesis, secretion, and inactivation | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Peptide hormone metabolism | ||||
Reactome | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | ||||
Reactome | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Incretin synthesis, secretion, and inactivation | ||||
Metabolism of proteins | ||||
Peptide hormone metabolism | ||||
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | ||||
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | ||||
Viral Interactions (0)
Gene Ontology Terms (36)
Functions (8)
Components (15)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | CACAO | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 5 | 4 | 4 | 6.5 | 94 | ||||
mathematical ability | 4 | 3 | 6 | 92.4 | |||||
cognitive function measurement | 3 | 3 | 4 | 89.8 | |||||
intelligence | 5 | 7 | 5 | 6.9 | 87.8 | ||||
smoking status measurement | 2 | 1 | 2 | 79.4 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 4 | 6.5 | 94 | ||||
mathematical ability | 6 | 92.4 | |||||
cognitive function measurement | 4 | 89.8 | |||||
intelligence | 5 | 6.9 | 87.8 | ||||
smoking status measurement | 2 | 79.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dipeptidyl peptidase 4 | VGNC:366 | 459689 | |||||
Macaque | dipeptidyl peptidase 4 | 654491 | ||||||
Mouse | MGI:94919 | 13482 | ||||||
Rat | RGD:2515 | 25253 | ||||||
Dog | dipeptidyl peptidase 4 | VGNC:40074 | 478767 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dipeptidyl peptidase 4 | |||||
Macaque | dipeptidyl peptidase 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dipeptidyl peptidase 4 | |||||
Publication Statistics
PubMed Score 6514.84
PubMed score by year
PubTator Score 3504.40
PubTator score by year
Related Publications
Text Mined References (432)
GeneRif Annotations (359)
Items per page:
0 of 0
PMID | Year | Title |
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