Tclin DPP4 Dipeptidyl peptidase 4

Protein Summary

Description

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P27487
• Q53TN1

Gene Name

• DPP4

Ensembl ID

• ENST00000360534
• ENSP00000353731
• ENSG00000197635

Symbol

• ADCP2
• CD26
• CD26
• ADABP
• ADCP2
• DPPIV
• TP103

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
drug	1
PubMedID	0.99
cellular component	0.98
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Dipeptidyl Peptidase 4

Protein / Enzyme Modulator / Dipeptidyl Peptidase 4

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Dipeptidyl Peptidase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7437.02   (req: < 5)

Gene RIFs: 359   (req: <= 3)

Antibodies: 1632   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7437.02   (req: >= 5)

Gene RIFs: 359   (req: > 3)

Antibodies: 1632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3393

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12