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Tbio
DPP10
Inactive dipeptidyl peptidase 10

Protein Summary
Description
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155). This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310323
  • ENSP00000309066
  • ENSG00000175497
  • ENST00000393147
  • ENSP00000376855
  • ENST00000409163
  • ENSP00000387038
  • ENST00000410059
  • ENSP00000386565

Symbol
  • DPRP3
  • KIAA1492
  • DPL2
  • DPPY
  • DPRP3
  • DPRP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
microRNA
0.79
transcription factor
0.7
gene perturbation
0.65
phenotype
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.78   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.78   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
67.7
mathematical ability
1
1
1
54.7
parathyroid hormone measurement
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
67.7
mathematical ability
1
54.7
parathyroid hormone measurement
1
26.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase like 10
VGNC:365
459565
Macaque
dipeptidyl peptidase like 10
714671
Mouse
MGI:2442409
269109
Rat
RGD:1306427
363972
Dog
dipeptidyl peptidase like 10
VGNC:40072
476121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dipeptidyl peptidase like 10
Macaque
dipeptidyl peptidase like 10
Mouse
Rat
Dog
dipeptidyl peptidase like 10
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N608-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (75)
1 – 10 of 75
KCND2
Tclin
Family: IC
Novelty: 0.00297203
Score: 0.842
Data Source: STRINGDB
KCNC1
Tclin
Family: IC
Novelty: 0.00252943
Score: 0.836
Data Source: STRINGDB
PHF11
Tbio
Family: Epigenetic
Novelty: 0.05827551
Score: 0.797
Data Source: STRINGDB
KCND3
Tclin
Family: IC
Novelty: 0.00328276
Score: 0.795
Data Source: STRINGDB
ADAM33
Tchem
Family: Enzyme
Novelty: 0.00584097
Score: 0.733
Data Source: STRINGDB
TMEM263
Tdark
Novelty: 0.64480022
Score: 0.708
Data Source: STRINGDB
KCNIP1
Tbio
Family: IC
Novelty: 0.01790042
Score: 0.7
Data Source: STRINGDB
NPSR1
Tchem
Family: GPCR
Novelty: 0.00562139
Score: 0.687
Data Source: STRINGDB
KCNA4
Tclin
Family: IC
Novelty: 0.00362065
Score: 0.683
Data Source: STRINGDB
KCNIP3
Tbio
Family: IC
Novelty: 0.01371555
Score: 0.677
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.78

PubMed score by year
PubTator Score  40.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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