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Tdark
DPM3
Dolichol-phosphate mannosyltransferase subunit 3

Protein Summary
Description
Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER. Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341298
  • ENSP00000344338
  • ENSG00000179085
  • ENST00000368399
  • ENSP00000357384
  • ENST00000368400
  • ENSP00000357385

Symbol
  • CDG1O
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.73
virus perturbation
0.72
histone modification site profile
0.7
kinase perturbation
0.66
biological process
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
DPM1
Tbio
Family:  Enzyme
Novelty:  0.01317862
Score:  0.997
Data Source:  Reactome,STRINGDB
DPM2
Tdark
Novelty:  0.04752556
Score:  0.997
Data Source:  Reactome,STRINGDB
DOLK
Tbio
Family:  Enzyme
Novelty:  0.00664639
Score:  0.983
Data Source:  STRINGDB
DPAGT1
Tbio
Family:  Enzyme
Novelty:  0.00869839
Score:  0.981
Data Source:  STRINGDB
ALG5
Tbio
Family:  Enzyme
Novelty:  0.04358658
Score:  0.957
Data Source:  STRINGDB
GMPPB
Tbio
Family:  Enzyme
Novelty:  0.05106206
Score:  0.956
Data Source:  STRINGDB
ALG1
Tbio
Family:  Enzyme
Novelty:  0.012911
Score:  0.954
Data Source:  STRINGDB
DOLPP1
Tdark
Family:  Enzyme
Novelty:  0.40497097
Score:  0.946
Data Source:  STRINGDB
PIGV
Tbio
Family:  Enzyme
Novelty:  0.05672936
Score:  0.929
Data Source:  STRINGDB
ALG3
Tbio
Family:  Enzyme
Novelty:  0.0159047
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective DPM1 causes DPM1-CDG (CDG-1e)
Reactome
Defective DPM2 causes DPM2-CDG (CDG-1u)
Reactome
Defective DPM3 causes DPM3-CDG (CDG-1o)
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective DPM1 causes DPM1-CDG (CDG-1e)
Defective DPM2 causes DPM2-CDG (CDG-1u)
Defective DPM3 causes DPM3-CDG (CDG-1o)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
HGNC
Disease Associations ()
No disease associations found
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
6
5
3.7
99.1
urate measurement
6
7
11
98.8
serum urea measurement
2
5
5
98.1
cancer antigen 15.3 measurement
1
2
2
93.8
3
3
0
1.3
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
3.7
99.1
urate measurement
11
98.8
serum urea measurement
5
98.1
cancer antigen 15.3 measurement
2
93.8
0
1.3
93.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dolichyl-phosphate mannosyltransferase subunit 3
VGNC:8039
469511
Macaque
dolichyl-phosphate mannosyltransferase subunit 3
717446
Mouse
MGI:1915813
68563
Rat
RGD:1561807
502017
Dog
dolichyl-phosphate mannosyltransferase subunit 3
VGNC:40071
490430
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dolichyl-phosphate mannosyltransferase subunit 3
Macaque
dolichyl-phosphate mannosyltransferase subunit 3
Mouse
Rat
Dog
dolichyl-phosphate mannosyltransferase subunit 3
Publication Statistics
PubMed Score 18.19
PubMed score by year
PubTator Score 14.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title