Tbio DPM1 Dolichol-phosphate mannosyltransferase subunit 1

Protein Summary

Description

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• O60762
• O15157
• Q6IB78
• Q96HK0

Gene Name

• DPM1

Ensembl ID

• ENST00000371588
• ENSP00000360644
• ENSG00000000419

Symbol

• MPDS
• CDGIE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
histone modification site profile	0.92
transcription factor binding site profile	0.84
ligand (protein) perturbation	0.83
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Dolichol-phosphate Mannosyltransferase Subunit 1

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Dolichol-phosphate Mannosyltransferase Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.91   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.91   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0