Tbio DPH7 Diphthine methyltransferase

Protein Summary

Description

Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q9BTV6
• Q96AB7

Gene Name

• DPH7

Ensembl ID

• ENST00000277540
• ENSP00000277540
• ENSG00000148399

Symbol

• C9orf112
• WDR85
• RRT2
• WDR85
• C9orf112

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.78
cell type or tissue	0.74
transcription factor	0.65
tissue sample	0.61
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.75   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.75   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (39)

Explore Interacting Targets

1 – 10 of 39

• See Interactions on String-DB

RALGAPA2

Tdark

Family:  Enzyme

Novelty:  0.12467725

p_int:  0.99995592

p_ni:  0.000044069

p_wrong:  1e-8

Score:  0.252

Data Source:  BioPlex,STRINGDB

ZNF446

Tdark

Family:  TF

Novelty:  0.80369039

p_int:  0.999653446

p_ni:  0.000346554

Score:  0.188

Data Source:  BioPlex,STRINGDB

RALGAPB

Tbio

Family:  Enzyme

Novelty:  0.31941838

p_int:  0.999343213

p_ni:  0.000656782

p_wrong:  5e-9

Score:  0.19

Data Source:  BioPlex,STRINGDB

NPB

Tdark

Novelty:  0.00936692

p_int:  0.956666583

p_ni:  0.043333415

p_wrong:  3e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

CCT2

Tbio

Novelty:  0.01967139

p_int:  0.928281133

p_ni:  0.071683308

p_wrong:  0.000035559

Data Source:  BioPlex

EEF2

Tchem

Novelty:  0.00064095

Score:  0.986

Data Source:  Reactome,STRINGDB

DPH2

Tbio

Novelty:  0.04268301

Score:  0.938

Data Source:  STRINGDB

DPH5

Tbio

Family:  Enzyme

Novelty:  0.09745698

Score:  0.924

Data Source:  STRINGDB

DPH1

Tbio

Novelty:  0.02296024

Score:  0.922

Data Source:  STRINGDB

DPH3

Tdark

Novelty:  0.05288317

Score:  0.895

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

UniProt (1)

Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	Synthesis of diphthamide-EEF2	8 targets	R-HSA-5358493

Name	Explore in Pharos	Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
Synthesis of diphthamide-EEF2	8 targets	R-HSA-5358493

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Functions (1)

Processes (1)

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GO Term	Evidence	Assigned by
diphthine methylesterase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
childhood onset asthma	EFO_0004591	1	1	0	1.3	30.2
asthma	EFO_0000270	1	1	0	1.1	30.2

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
childhood onset asthma	EFO_0004591	0	1.3	30.2
asthma	EFO_0000270	0	1.1	30.2

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UniProt Keyword Find Similar Targets

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Complete proteome
Hydrolase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
WD repeat

GWAS Trait Find Similar Targets

No Header	No Header
asthma
childhood onset asthma

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	diphthamide biosynthesis 7	VGNC:13871	737266
Macaque	diphthamide biosynthesis 7		703764
Mouse	diphthamine biosynethesis 7	MGI:1914478	67228
Rat	diphthamide biosynthesis 7	RGD:1304868	296550
Dog	diphthamide biosynthesis 7	VGNC:53234	100688792

Species	Name	OMA	EggNOG	Inparanoid
Chimp	diphthamide biosynthesis 7
Macaque	diphthamide biosynthesis 7
Mouse	diphthamine biosynethesis 7
Rat	diphthamide biosynthesis 7
Dog	diphthamide biosynthesis 7

Publication Statistics

PubMed Score 15.75

PubMed score by year

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PubTator Score 3.23

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (1)

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PMID	Year	Title