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Tbio
DPH7
Diphthine methyltransferase

Protein Summary
Description
Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277540
  • ENSP00000277540
  • ENSG00000148399

Symbol
  • C9orf112
  • WDR85
  • RRT2
  • WDR85
  • C9orf112
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.78
cell type or tissue
0.74
transcription factor
0.65
tissue sample
0.61
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.75   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.75   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
RALGAPA2
Tdark
Family:  Enzyme
Novelty:  0.12467725
p_int:  0.99995592
p_ni:  0.000044069
p_wrong:  1e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
ZNF446
Tdark
Family:  TF
Novelty:  0.80369039
p_int:  0.999653446
p_ni:  0.000346554
Score:  0.188
Data Source:  BioPlex,STRINGDB
RALGAPB
Tbio
Family:  Enzyme
Novelty:  0.31941838
p_int:  0.999343213
p_ni:  0.000656782
p_wrong:  5e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
NPB
Tdark
Novelty:  0.00936692
p_int:  0.956666583
p_ni:  0.043333415
p_wrong:  3e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.928281133
p_ni:  0.071683308
p_wrong:  0.000035559
Data Source:  BioPlex
EEF2
Tchem
Novelty:  0.00064095
Score:  0.986
Data Source:  Reactome,STRINGDB
DPH2
Tbio
Novelty:  0.04268301
Score:  0.938
Data Source:  STRINGDB
DPH5
Tbio
Family:  Enzyme
Novelty:  0.09745698
Score:  0.924
Data Source:  STRINGDB
DPH1
Tbio
Novelty:  0.02296024
Score:  0.922
Data Source:  STRINGDB
DPH3
Tdark
Novelty:  0.05288317
Score:  0.895
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of diphthamide-EEF2
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Metabolism of proteins
Post-translational protein modification
Synthesis of diphthamide-EEF2
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
1
1
0
1.3
30.2
1
1
0
1.1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.3
30.2
0
1.1
30.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diphthamide biosynthesis 7
VGNC:13871
737266
Macaque
diphthamide biosynthesis 7
703764
Mouse
MGI:1914478
67228
Rat
RGD:1304868
296550
Dog
diphthamide biosynthesis 7
VGNC:53234
100688792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diphthamide biosynthesis 7
Macaque
diphthamide biosynthesis 7
Mouse
Rat
Dog
diphthamide biosynthesis 7
Publication Statistics
PubMed Score 15.75
PubMed score by year
PubTator Score 3.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title