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Tbio
DPH5
Diphthine methyl ester synthase

Protein Summary
Description
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342173
  • ENSP00000339630
  • ENSG00000117543
  • ENST00000370109
  • ENSP00000359127
  • ENST00000488176
  • ENSP00000418282

Symbol
  • AD-018
  • CGI-30
  • NPD015
  • HSPC143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
disease perturbation
0.83
kinase perturbation
0.81
virus perturbation
0.79
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
EEF2
Tchem
Novelty:  0.00064095
Score:  0.995
Data Source:  Reactome,STRINGDB
DPH6
Tbio
Family:  Enzyme
Novelty:  0.15211179
Score:  0.987
Data Source:  STRINGDB
DPH1
Tbio
Novelty:  0.02296024
Score:  0.975
Data Source:  STRINGDB
DPH2
Tbio
Novelty:  0.04268301
Score:  0.972
Data Source:  STRINGDB
DPH7
Tbio
Family:  Enzyme
Novelty:  0.05925085
Score:  0.924
Data Source:  STRINGDB
DPH3
Tdark
Novelty:  0.05288317
Score:  0.923
Data Source:  STRINGDB
ZYX
Tbio
Novelty:  0.00375452
Score:  0.866
Data Source:  STRINGDB
SNU13
Tbio
Novelty:  0.01613497
Score:  0.86
Data Source:  STRINGDB
NIP7
Tbio
Novelty:  0.05885055
Score:  0.844
Data Source:  STRINGDB
NHP2
Tbio
Novelty:  0.01414024
Score:  0.837
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of diphthamide-EEF2
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Metabolism of proteins
Post-translational protein modification
Synthesis of diphthamide-EEF2
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
54.2
lymphocyte count
1
1
1
11.8
monocyte percentage of leukocytes
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
54.2
lymphocyte count
1
11.8
monocyte percentage of leukocytes
1
6.6
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diphthamide biosynthesis 5
VGNC:521
457062
Macaque
diphthamide biosynthesis 5
712253
Mouse
MGI:1916990
69740
Rat
RGD:1307867
295394
Dog
diphthamide biosynthesis 5
VGNC:40069
612092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diphthamide biosynthesis 5
Macaque
diphthamide biosynthesis 5
Mouse
Rat
Dog
diphthamide biosynthesis 5
Publication Statistics
PubMed Score 9.13
PubMed score by year
PubTator Score 1.07
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title