Tbio DPH5 Diphthine methyl ester synthase

Protein Summary

Description

S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H2P9
• A8JZY6
• D3DT62
• Q9P017
• Q9P0I4
• Q9Y319

Gene Name

• DPH5

Ensembl ID

• ENST00000342173
• ENSP00000339630
• ENSG00000117543
• ENST00000370109
• ENSP00000359127
• ENST00000488176
• ENSP00000418282

Symbol

• AD-018
• CGI-30
• NPD015
• HSPC143

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
disease perturbation	0.83
kinase perturbation	0.81
virus perturbation	0.79
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Diphthine Methyl Ester Synthase

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Diphthine Methyl Ester Synthase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.18   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 21   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.18   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0