Protein Summary
Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
- ENST00000383775
- ENSP00000373285
- ENSG00000154813
- ENST00000488423
- ENSP00000419599
- DESR1
- ZCSL2
- DESR1
- DPH3A
- KTI11
- ZCSL2
- DELGIP
- DELGIP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.89 | ||
transcription factor binding site profile | 0.84 | ||
transcription factor perturbation | 0.84 | ||
kinase perturbation | 0.76 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.67 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 36 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.67 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 36 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (48)
SERGEF
Novelty: 0.36520994
p_int: 0.999999994
p_ni: 6e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
DPH2
Novelty: 0.04268301
p_int: 0.999972588
p_ni: 0.000027409
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
ATE1
Family: Enzyme
Novelty: 0.01672896
p_int: 0.995621669
p_ni: 0.004378331
Score: 0.189
Data Source: BioPlex,STRINGDB
NEK7
Family: Kinase
Novelty: 0.02675561
p_int: 0.836939113
p_ni: 0.076238122
p_wrong: 0.086822765
Score: 0.243
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Synthesis of diphthamide-EEF2 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Synthesis of diphthamide-EEF2 | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (1)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | diphthamide biosynthesis 3 | 695309 | ||||||
Mouse | MGI:1922658 | 105638 | ||||||
Rat | RGD:1590566 | 680594 | ||||||
Dog | diphthamide biosynthesis 3 | VGNC:52874 | 610533 | |||||
Horse | diphthamide biosynthesis 3 | 100052302 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | diphthamide biosynthesis 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | diphthamide biosynthesis 3 | |||||
Horse | diphthamide biosynthesis 3 | |||||
Publication Statistics
PubMed Score 20.67
PubMed score by year
PubTator Score 5.57
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (3)
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