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Tdark
DPH3
DPH3 homolog

Protein Summary
Description
Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383775
  • ENSP00000373285
  • ENSG00000154813
  • ENST00000488423
  • ENSP00000419599

Symbol
  • DESR1
  • ZCSL2
  • DESR1
  • DPH3A
  • KTI11
  • ZCSL2
  • DELGIP
  • DELGIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.84
transcription factor perturbation
0.84
kinase perturbation
0.76
virus perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
SERGEF
Tdark
Novelty:  0.36520994
p_int:  0.999999994
p_ni:  6e-9
Score:  0.978
Data Source:  BioPlex,STRINGDB
DPH2
Tbio
Novelty:  0.04268301
p_int:  0.999972588
p_ni:  0.000027409
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.995621669
p_ni:  0.004378331
Score:  0.189
Data Source:  BioPlex,STRINGDB
NEK7
Tchem
Family:  Kinase
Novelty:  0.02675561
p_int:  0.836939113
p_ni:  0.076238122
p_wrong:  0.086822765
Score:  0.243
Data Source:  BioPlex,STRINGDB
DPH1
Tbio
Novelty:  0.02296024
Score:  0.996
Data Source:  Reactome,STRINGDB
EEF2
Tchem
Novelty:  0.00064095
Score:  0.984
Data Source:  STRINGDB
DPH5
Tbio
Family:  Enzyme
Novelty:  0.09745698
Score:  0.923
Data Source:  STRINGDB
DPH7
Tbio
Family:  Enzyme
Novelty:  0.05925085
Score:  0.895
Data Source:  STRINGDB
ELP3
Tbio
Family:  Epigenetic
Novelty:  0.0166061
Score:  0.88
Data Source:  STRINGDB
DPH6
Tbio
Family:  Enzyme
Novelty:  0.15211179
Score:  0.872
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of diphthamide-EEF2
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Metabolism of proteins
Post-translational protein modification
Synthesis of diphthamide-EEF2
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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10
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GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
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IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
diphthamide biosynthesis 3
695309
Mouse
MGI:1922658
105638
Rat
RGD:1590566
680594
Dog
diphthamide biosynthesis 3
VGNC:52874
610533
Horse
diphthamide biosynthesis 3
100052302
Species
Name
OMA
EggNOG
Inparanoid
Macaque
diphthamide biosynthesis 3
Mouse
Rat
Dog
diphthamide biosynthesis 3
Horse
diphthamide biosynthesis 3
Publication Statistics
PubMed Score 20.67
PubMed score by year
PubTator Score 5.57
PubTator score by year
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Related Publications
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PMID
Year
Title