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Tbio
DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Protein Summary
Description
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255108
  • ENSP00000255108
  • ENSG00000132768
  • ENST00000396758
  • ENSP00000379981

Symbol
  • DPH2L2
  • DPH2L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
histone modification site profile
0.74
tissue sample
0.65
transcription factor binding site profile
0.64
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 353   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
IL17B
Tbio
Novelty:  0.02825795
p_int:  0.999995572
p_ni:  0.000004428
Data Source:  BioPlex
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.99998305
p_ni:  0.000011571
p_wrong:  0.000005379
Data Source:  BioPlex
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.999980086
p_ni:  0.000019913
Data Source:  BioPlex
DPH3
Tdark
Novelty:  0.05288317
p_int:  0.999972588
p_ni:  0.000027409
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
FAM219B
Tdark
Novelty:  5.26378794
p_int:  0.999702604
p_ni:  0.000262
p_wrong:  0.000035396
Score:  0.228
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.999643918
p_ni:  0.000339815
p_wrong:  0.000016267
Data Source:  BioPlex
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999432277
p_ni:  0.000400241
p_wrong:  0.000167482
Data Source:  BioPlex
WIPI2
Tbio
Novelty:  0.02685992
p_int:  0.998650698
p_ni:  0.000137905
p_wrong:  0.001211398
Score:  0.295
Data Source:  BioPlex,STRINGDB
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.996868757
p_ni:  0.001768317
p_wrong:  0.001362926
Data Source:  BioPlex
HSPBP1
Tbio
Novelty:  0.01176285
p_int:  0.928332163
p_ni:  0.000451418
p_wrong:  0.071216419
Score:  0.242
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of diphthamide-EEF2
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Metabolism of proteins
Post-translational protein modification
Synthesis of diphthamide-EEF2
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
6
80.5
intelligence
4
4
2
6
76.1
cognitive function measurement
3
2
3
66.3
household income
1
2
2
60.8
age at first sexual intercourse measurement
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
6
80.5
intelligence
2
6
76.1
cognitive function measurement
3
66.3
household income
2
60.8
age at first sexual intercourse measurement
1
52
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DPH2 homolog
702123
Mouse
MGI:1914978
67728
Rat
RGD:1304634
298452
Dog
DPH2 homolog
VGNC:40068
475387
Horse
DPH2 homolog
VGNC:17288
100053064
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DPH2 homolog
Mouse
Rat
Dog
DPH2 homolog
Horse
DPH2 homolog
Publication Statistics
PubMed Score 25.40
PubMed score by year
PubTator Score 3.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title