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Tbio
DPF3
Zinc finger protein DPF3

Protein Summary
Description
Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex invol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381216
  • ENSP00000370614
  • ENSG00000205683
  • ENST00000541685
  • ENSP00000441640
  • ENST00000546183
  • ENSP00000444662
  • ENST00000556509
  • ENSP00000450518
  • ENST00000614862
  • ENSP00000481992

Symbol
  • BAF45C
  • CERD4
  • CERD4
  • BAF45C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.74
transcription factor
0.72
kinase perturbation
0.71
histone modification site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  1
Score:  0.985
Data Source:  BioPlex,STRINGDB
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  1
Score:  0.984
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999999993
p_ni:  7e-9
Score:  0.877
Data Source:  BioPlex,STRINGDB
ARID1B
Tbio
Family:  TF
Novelty:  0.00731933
p_int:  0.999999807
p_ni:  1.93e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
BRD7
Tchem
Family:  Epigenetic
Novelty:  0.01820848
p_int:  0.99999956
p_ni:  4.4e-7
Score:  0.988
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999999459
p_ni:  5.41e-7
Score:  0.899
Data Source:  BioPlex,STRINGDB
SMARCD3
Tbio
Novelty:  0.03423481
p_int:  0.999999367
p_ni:  6.33e-7
Score:  0.986
Data Source:  BioPlex,STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
p_int:  0.999999148
p_ni:  7.72e-7
p_wrong:  8e-8
Score:  0.224
Data Source:  BioPlex,STRINGDB
SMARCA2
Tchem
Family:  Epigenetic
Novelty:  0.00231554
p_int:  0.999998698
p_ni:  0.000001302
Score:  0.978
Data Source:  BioPlex,STRINGDB
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999997816
p_ni:  0.000002183
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
4
6
97.2
alkaline phosphatase measurement
2
1
1
10.2
82.3
sex hormone-binding globulin measurement
6
1
6
81.3
2
1
0
1.3
76.4
hematocrit
2
1
2
66
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
97.2
alkaline phosphatase measurement
1
10.2
82.3
sex hormone-binding globulin measurement
6
81.3
0
1.3
76.4
hematocrit
2
66
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1917377
70127
Rat
RGD:1309052
299186
Dog
double PHD fingers 3
VGNC:50524
611798
Horse
double PHD fingers 3
VGNC:17286
100055250
Cow
double PHD fingers 3
VGNC:28177
787359
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
double PHD fingers 3
Horse
double PHD fingers 3
Cow
double PHD fingers 3
Publication Statistics
PubMed Score 15.45
PubMed score by year
PubTator Score 6.47
PubTator score by year
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Related Publications
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PMID
Year
Title