You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DPF2
Zinc finger protein ubi-d4

Protein Summary
Description
Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000415073
  • ENSP00000399714
  • ENSG00000133884
  • ENST00000528416
  • ENSP00000436901

Symbol
  • BAF45D
  • REQ
  • UBID4
  • REQ
  • CSS7
  • UBID4
  • ubi-d4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
protein domain
0.97
interacting protein
0.94
drug perturbation
0.87
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.71   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.71   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  1
Score:  0.945
Data Source:  BioPlex,STRINGDB
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.999999995
p_ni:  5e-9
Score:  0.944
Data Source:  BioPlex,STRINGDB
ARID1B
Tbio
Family:  TF
Novelty:  0.00731933
p_int:  0.999999617
p_ni:  3.8e-7
p_wrong:  3e-9
Score:  0.963
Data Source:  BioPlex,STRINGDB
SMARCA2
Tchem
Family:  Epigenetic
Novelty:  0.00231554
p_int:  0.999998985
p_ni:  0.000001015
Score:  0.914
Data Source:  BioPlex,STRINGDB
SMARCD3
Tbio
Novelty:  0.03423481
p_int:  0.999997894
p_ni:  0.000002106
Score:  0.924
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999997771
p_ni:  0.000002229
Score:  0.925
Data Source:  BioPlex,STRINGDB
SS18L1
Tbio
Novelty:  0.10255799
p_int:  0.999997182
p_ni:  0.000002815
p_wrong:  3e-9
Score:  0.933
Data Source:  BioPlex,STRINGDB
SMARCD2
Tbio
Novelty:  0.04006597
p_int:  0.999996605
p_ni:  0.000003395
Score:  0.924
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999995792
p_ni:  0.000004208
Score:  0.947
Data Source:  BioPlex,STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
p_int:  0.999995508
p_ni:  0.000004492
Score:  0.955
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
2
2
3
88.9
glomerular filtration rate
1
2
2
88.5
uric acid measurement
1
1
1
78.9
BMI-adjusted hip circumference
1
3
3
74.6
serum alanine aminotransferase measurement
2
2
1
7.3
69.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
88.9
glomerular filtration rate
2
88.5
uric acid measurement
1
78.9
BMI-adjusted hip circumference
3
74.6
serum alanine aminotransferase measurement
1
7.3
69.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
double PHD fingers 2
VGNC:7647
451321
Macaque
double PHD fingers 2
721967
Mouse
MGI:109529
19708
Rat
RGD:1311699
361711
Dog
double PHD fingers 2
VGNC:40066
483743
Species
Name
OMA
EggNOG
Inparanoid
Chimp
double PHD fingers 2
Macaque
double PHD fingers 2
Mouse
Rat
Dog
double PHD fingers 2
Publication Statistics
PubMed Score 27.71
PubMed score by year
PubTator Score 11.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title