Tbio DPF1 Zinc finger protein neuro-d4

Protein Summary

Description

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Uniprot Accession IDs

• Q92782
• B3KSY8
• Q08AJ0

Gene Name

• DPF1

Ensembl ID

• ENST00000355526
• ENSP00000347716
• ENSG00000011332
• ENST00000412732
• ENSP00000412098
• ENST00000414789
• ENSP00000391884
• ENST00000420980
• ENSP00000397354

Symbol

• BAF45B
• NEUD4
• NEUD4
• BAF45b
• neuro-d4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
cell type or tissue	0.75
transcription factor	0.75
gene perturbation	0.58
small molecule perturbation	0.54

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Zinc Finger Protein Neuro-d4

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein Neuro-d4

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Zinc Finger Protein Neuro-d4

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Zinc Finger Protein Neuro-d4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.29   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.29   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (40)

Explore Interacting Targets

1 – 10 of 40

• See Interactions on String-DB

SMARCC2

Tbio

Family:  TF; Epigenetic

Novelty:  0.02625321

p_int:  0.99999966

p_ni:  3.29e-7

p_wrong:  1.1e-8

Score:  0.98

Data Source:  BioPlex,STRINGDB

SMARCB1

Tbio

Novelty:  0.00116387

p_int:  0.999999003

p_ni:  9.95e-7

p_wrong:  2e-9

Score:  0.972

Data Source:  BioPlex,STRINGDB

SMARCD1

Tbio

Novelty:  0.03176642

p_int:  0.999998801

p_ni:  0.000001195

p_wrong:  5e-9

Score:  0.979

Data Source:  BioPlex,STRINGDB

SS18

Tbio

Novelty:  0.00915548

p_int:  0.999997833

p_ni:  0.00000206

p_wrong:  1.07e-7

Score:  0.935

Data Source:  BioPlex,STRINGDB

BCL7C

Tdark

Novelty:  0.31203802

p_int:  0.999996717

p_ni:  0.000003278

p_wrong:  5e-9

Score:  0.851

Data Source:  BioPlex,STRINGDB

BCL7A

Tbio

Novelty:  0.07026394

p_int:  0.99999374

p_ni:  0.000006255

p_wrong:  4e-9

Score:  0.837

Data Source:  BioPlex,STRINGDB

SMARCE1

Tbio

Family:  TF

Novelty:  0.01748089

p_int:  0.999720017

p_ni:  0.000148867

p_wrong:  0.000131117

Score:  0.979

Data Source:  BioPlex,STRINGDB

ACTL6B

Tbio

Novelty:  0.05740204

Score:  0.945

Data Source:  STRINGDB

SMARCC1

Tbio

Family:  TF; Epigenetic

Novelty:  0.00961765

Score:  0.913

Data Source:  STRINGDB

SMARCA4

Tchem

Family:  Epigenetic

Novelty:  0.00112496

Score:  0.906

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (39)

KEGG (2)

WikiPathways (37)

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Thermogenesis	234 targets	path:hsa04714
KEGG	Hepatocellular carcinoma	168 targets	path:hsa05225

Name	Explore in Pharos	Explore in Source
Thermogenesis	234 targets	path:hsa04714
Hepatocellular carcinoma	168 targets	path:hsa05225

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (3)

Components (5)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
histone acetyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
histone binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	5	3	0	1.1	92.5
platelet count	EFO_0004309	2	2	2		85.2
calcium measurement	EFO_0004838	1	1	1		63.7
mathematical ability	EFO_0004875	2	2	2		63
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1		59

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	0	1.1	92.5
platelet count	EFO_0004309	2		85.2
calcium measurement	EFO_0004838	1		63.7
mathematical ability	EFO_0004875	2		63
serum gamma-glutamyl transferase measurement	EFO_0004532	1		59

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasm
Isopeptide bond
Metal-binding
Neurogenesis
Nucleus
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
calcium measurement
cancer
mathematical ability
mean platelet volume
platelet count
platelet crit
prostate carcinoma
serum alanine aminotransferase measurement
serum gamma-glutamyl transferase measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	double PHD fingers 1	VGNC:7555	748599
Macaque	double PHD fingers 1		719503
Mouse	D4, zinc and double PHD fingers family 1	MGI:1352748	29861
Rat	double PHD fingers 1	RGD:61868	50545
Dog	double PHD fingers 1	VGNC:40065	484535

Species	Name	OMA	EggNOG	Inparanoid
Chimp	double PHD fingers 1
Macaque	double PHD fingers 1
Mouse	D4, zinc and double PHD fingers family 1
Rat	double PHD fingers 1
Dog	double PHD fingers 1

Publication Statistics

PubMed Score 12.29

PubMed score by year

Reset Zoom

PubTator Score 6.21

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (4)

Items per page:

10

0 of 0

PMID	Year	Title