Tbio DPF1 Zinc finger protein neuro-d4

Protein Summary

Description

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Uniprot Accession IDs

• Q92782
• B3KSY8
• Q08AJ0

Gene Name

• DPF1

Ensembl ID

• ENST00000355526
• ENSP00000347716
• ENSG00000011332
• ENST00000412732
• ENSP00000412098
• ENST00000414789
• ENSP00000391884
• ENST00000420980
• ENSP00000397354

Symbol

• BAF45B
• NEUD4
• NEUD4
• BAF45b
• neuro-d4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
cell type or tissue	0.75
transcription factor	0.75
gene perturbation	0.58
small molecule perturbation	0.54

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Zinc Finger Protein Neuro-d4

Protein / Transcription Factor / Zinc Finger Transcription Factor / Zinc Finger Protein Neuro-d4

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Zinc Finger Protein Neuro-d4

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Zinc Finger Protein Neuro-d4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.27   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.27   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0