Tbio DPEP2 Dipeptidase 2

Protein Summary

Description

Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9H4A9
• A0A024R6Y5
• B2RCF8
• B3KS59
• I3L248
• Q6UX92
• Q8TC95

Gene Name

• DPEP2

Ensembl ID

• ENST00000393847
• ENSP00000377430
• ENSG00000167261
• ENST00000572888
• ENSP00000458977
• ENST00000575203
• ENSP00000459375

Symbol

• MBD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.64
cell type or tissue	0.57
co-expressed gene	0.57
molecular function	0.53
cell line	0.5

Protein Classes

DTO Classes

N-acetylated-alpha-linked Acidic Dipeptidase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.8   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.8   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0