Protein Summary
Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
- ENST00000261615
- ENSP00000261615
- ENSG00000015413
- ENST00000393092
- ENSP00000376807
- ENST00000421184
- ENSP00000397313
- MDP
- RDP
- MDP
- RDP
- MBD1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
biological process | 0.83 | ||
cellular component | 0.83 | ||
gene perturbation | 0.7 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 264.74 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 202 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 264.74 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 202 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 19
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (19)
Protein-Protein Interactions (89)
STEAP3
Family: Enzyme
Novelty: 0.02042104
p_int: 0.999952402
p_ni: 0.000047498
p_wrong: 1.01e-7
Data Source: BioPlex
PIGA
Family: Enzyme
Novelty: 0.00172769
p_int: 0.999916938
p_ni: 0.000083062
Data Source: BioPlex
C1GALT1
Family: Enzyme
Novelty: 0.01191596
p_int: 0.999766073
p_ni: 0.00023366
p_wrong: 2.67e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (11)
Reactome (7)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aflatoxin activation and detoxification | ||||
Reactome | Arachidonic acid metabolism | ||||
Reactome | Biological oxidations | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aflatoxin activation and detoxification | ||||
Arachidonic acid metabolism | ||||
Biological oxidations | ||||
Fatty acid metabolism | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (8)
Components (9)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (41)
Items per page:
1 – 5 of 41
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hair color | 4 | 5 | 1 | 2.3 | 99.1 | ||||
suntan | 1 | 4 | 4 | 98.9 | |||||
5 | 2 | 0 | 1.7 | 93.7 | |||||
body height | 2 | 2 | 2 | 92.6 | |||||
glomerular filtration rate | 6 | 5 | 5 | 5.5 | 92.5 | ||||
Items per page:
1 – 5 of 41
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hair color | 1 | 2.3 | 99.1 | ||||
suntan | 4 | 98.9 | |||||
0 | 1.7 | 93.7 | |||||
body height | 2 | 92.6 | |||||
glomerular filtration rate | 5 | 5.5 | 92.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | dipeptidase 1 | 699725 | ||||||
Mouse | MGI:94917 | 13479 | ||||||
Rat | RGD:620324 | 94199 | ||||||
Dog | dipeptidase 1 | VGNC:49599 | 479611 | |||||
Horse | dipeptidase 1 | VGNC:49047 | 100052197 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | dipeptidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dipeptidase 1 | |||||
Horse | dipeptidase 1 | |||||
Publication Statistics
PubMed Score 264.74
PubMed score by year
PubTator Score 178.57
PubTator score by year
Related Publications
Text Mined References (35)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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