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Tbio
DPAGT1
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Protein Summary
Description
Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol. The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354202
  • ENSP00000346142
  • ENSG00000172269
  • ENST00000409993
  • ENSP00000386597

Symbol
  • DPAGT2
  • GPT
  • ALG7
  • DGPT
  • G1PT
  • UAGT
  • UGAT
  • CDG1J
  • CMS13
  • DPAGT
  • CDG-Ij
  • CMSTA2
  • DPAGT2
  • D11S366
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
disease perturbation
0.93
kinase perturbation
0.93
cellular component
0.7
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.2   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.2   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
ARMCX4
Tdark
Novelty:  0.60877479
p_int:  0.999875487
p_ni:  1.1e-8
p_wrong:  0.000124502
Score:  0.517
Data Source:  BioPlex,STRINGDB
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.994886413
p_ni:  0.000003312
p_wrong:  0.005110275
Score:  0.185
Data Source:  BioPlex,STRINGDB
ST3GAL2
Tbio
Family:  Enzyme
Novelty:  0.03503891
p_int:  0.994384775
p_ni:  0.005614996
p_wrong:  2.3e-7
Score:  0.347
Data Source:  BioPlex,STRINGDB
STX4
Tbio
Novelty:  0.00831588
p_int:  0.892971466
p_ni:  0.107028368
p_wrong:  1.66e-7
Score:  0.191
Data Source:  BioPlex,STRINGDB
RAB21
Tbio
Family:  Enzyme
Novelty:  0.03221825
p_int:  0.851062615
p_ni:  0.148937269
p_wrong:  1.16e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
p_int:  0.819818285
p_ni:  0.176985618
p_wrong:  0.003196097
Data Source:  BioPlex
ALOX12B
Tbio
Family:  Enzyme
Novelty:  0.02778552
p_int:  0.773526476
p_ni:  0.226473524
Data Source:  BioPlex
ALG5
Tbio
Family:  Enzyme
Novelty:  0.04358658
Score:  0.996
Data Source:  STRINGDB
ALG14
Tbio
Family:  Enzyme
Novelty:  0.09271278
Score:  0.996
Data Source:  STRINGDB
DPM1
Tbio
Family:  Enzyme
Novelty:  0.01317862
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Disease
Diseases associated with N-glycosylation of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
4
5
97.4
platelet count
3
3
4
96.4
mean reticulocyte volume
1
2
2
94.6
lymphocyte count
3
3
3
88.2
body mass index
3
3
3
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
5
97.4
platelet count
4
96.4
mean reticulocyte volume
2
94.6
lymphocyte count
3
88.2
body mass index
3
79.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
VGNC:6754
451602
Macaque
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
703538
Mouse
MGI:1196396
13478
Rat
RGD:735124
300668
Dog
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
VGNC:40064
489371
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Macaque
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Mouse
Rat
Dog
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Publication Statistics
PubMed Score 128.20
PubMed score by year
PubTator Score 68.82
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title