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Tdark
DOLPP1
Dolichyldiphosphatase 1

Protein Summary
Description
Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity). A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372546
  • ENSP00000361625
  • ENSG00000167130
  • ENST00000406974
  • ENSP00000384043

Symbol
  • LSFR2
  • LSFR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
histone modification site profile
0.8
transcription factor
0.68
tissue sample
0.65
transcription factor binding site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.79   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.79   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.998299303
p_ni:  0.001696575
p_wrong:  0.000004122
Score:  0.175
Data Source:  BioPlex,STRINGDB
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.994950818
p_ni:  0.00504918
p_wrong:  1e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.981315583
p_ni:  0.018684411
p_wrong:  5e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.970907627
p_ni:  0.028852589
p_wrong:  0.000239784
Score:  0.183
Data Source:  BioPlex,STRINGDB
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.838352405
p_ni:  0.161634242
p_wrong:  0.000013353
Score:  0.198
Data Source:  BioPlex,STRINGDB
DOLK
Tbio
Family:  Enzyme
Novelty:  0.00664639
Score:  0.974
Data Source:  STRINGDB
ALG5
Tbio
Family:  Enzyme
Novelty:  0.04358658
Score:  0.97
Data Source:  STRINGDB
DPM1
Tbio
Family:  Enzyme
Novelty:  0.01317862
Score:  0.967
Data Source:  STRINGDB
DPAGT1
Tbio
Family:  Enzyme
Novelty:  0.00869839
Score:  0.96
Data Source:  STRINGDB
DPM3
Tdark
Family:  Enzyme
Novelty:  0.05248147
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of Dolichyl-phosphate
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of Dolichyl-phosphate
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
4
7
98.1
red blood cell distribution width
4
3
4
95.2
urinary metabolite measurement
1
1
1
61.4
red blood cell density measurement
1
1
1
53.3
systolic blood pressure
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
7
98.1
red blood cell distribution width
4
95.2
urinary metabolite measurement
1
61.4
red blood cell density measurement
1
53.3
systolic blood pressure
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dolichyldiphosphatase 1
VGNC:4680
107976793
Macaque
dolichyldiphosphatase 1
722572
Mouse
MGI:1914093
57170
Rat
RGD:1307447
296624
Dog
dolichyldiphosphatase 1
VGNC:40061
612827
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dolichyldiphosphatase 1
Macaque
dolichyldiphosphatase 1
Mouse
Rat
Dog
dolichyldiphosphatase 1
Publication Statistics
PubMed Score 1.79
PubMed score by year
PubTator Score 0.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title