Protein Summary
Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity). A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
- ENST00000372546
- ENSP00000361625
- ENSG00000167130
- ENST00000406974
- ENSP00000384043
- LSFR2
- LSFR2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
histone modification site profile | 0.8 | ||
transcription factor | 0.68 | ||
tissue sample | 0.65 | ||
transcription factor binding site profile | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.79 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 69 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.79 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 69 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (86)
SELENBP1
Novelty: 0.00758018
p_int: 0.998299303
p_ni: 0.001696575
p_wrong: 0.000004122
Score: 0.175
Data Source: BioPlex,STRINGDB
HEPHL1
Novelty: 0.44678065
p_int: 0.994950818
p_ni: 0.00504918
p_wrong: 1e-9
Score: 0.186
Data Source: BioPlex,STRINGDB
LRRC15
Novelty: 0.03701624
p_int: 0.981315583
p_ni: 0.018684411
p_wrong: 5e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
VSIG8
Novelty: 1.16023405
p_int: 0.970907627
p_ni: 0.028852589
p_wrong: 0.000239784
Score: 0.183
Data Source: BioPlex,STRINGDB
LYG2
Family: Enzyme
Novelty: 0.12091256
p_int: 0.838352405
p_ni: 0.161634242
p_wrong: 0.000013353
Score: 0.198
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (6)
KEGG (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Synthesis of Dolichyl-phosphate | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Synthesis of Dolichyl-phosphate | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood metabolite measurement | 3 | 4 | 7 | 98.1 | |||||
red blood cell distribution width | 4 | 3 | 4 | 95.2 | |||||
urinary metabolite measurement | 1 | 1 | 1 | 61.4 | |||||
red blood cell density measurement | 1 | 1 | 1 | 53.3 | |||||
systolic blood pressure | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood metabolite measurement | 7 | 98.1 | |||||
red blood cell distribution width | 4 | 95.2 | |||||
urinary metabolite measurement | 1 | 61.4 | |||||
red blood cell density measurement | 1 | 53.3 | |||||
systolic blood pressure | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dolichyldiphosphatase 1 | VGNC:4680 | 107976793 | |||||
Macaque | dolichyldiphosphatase 1 | 722572 | ||||||
Mouse | MGI:1914093 | 57170 | ||||||
Rat | RGD:1307447 | 296624 | ||||||
Dog | dolichyldiphosphatase 1 | VGNC:40061 | 612827 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dolichyldiphosphatase 1 | |||||
Macaque | dolichyldiphosphatase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dolichyldiphosphatase 1 | |||||
Publication Statistics
PubMed Score 1.79
PubMed score by year
PubTator Score 0.33
PubTator score by year
Related Publications
Text Mined References (9)
Items per page:
0 of 0
PMID | Year | Title |
|---|