Tbio DOLK Dolichol kinase

Protein Summary

Description

Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q9UPQ8
• Q5SRE6

Gene Name

• DOLK

Ensembl ID

• ENST00000372586
• ENSP00000361667
• ENSG00000175283

Symbol

• KIAA1094
• TMEM15
• DK
• DK1
• CDG1M
• SEC59
• TMEM15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
kinase perturbation	0.91
histone modification site profile	0.9
virus perturbation	0.9
tissue sample	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 70   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (92)

Explore Interacting Targets

1 – 10 of 92

• See Interactions on String-DB

OPALIN

Tdark

Novelty:  0.08221612

p_int:  0.999536341

p_ni:  0.000463026

p_wrong:  6.33e-7

Data Source:  BioPlex

KCNA6

Tclin

Family:  IC

Novelty:  18.19090909

p_int:  0.999343011

p_ni:  0.000528213

p_wrong:  0.000128776

Score:  0.234

Data Source:  BioPlex,STRINGDB

TNFRSF1A

Tchem

Novelty:  0.00037847

p_int:  0.998829042

p_ni:  0.001084126

p_wrong:  0.000086833

Data Source:  BioPlex

CD274

Tclin

Novelty:  0.00013449

p_int:  0.996846914

p_ni:  0.003124411

p_wrong:  0.000028675

Data Source:  BioPlex

FPR2

Tchem

Family:  GPCR

Novelty:  0.00228744

p_int:  0.996482621

p_ni:  0.003154789

p_wrong:  0.000362589

Data Source:  BioPlex

ERGIC3

Tbio

Novelty:  0.11095443

p_int:  0.995591599

p_ni:  0.004345223

p_wrong:  0.000063178

Score:  0.154

Data Source:  BioPlex,STRINGDB

KCNA5

Tclin

Family:  IC

Novelty:  0.00182891

p_int:  0.991048698

p_ni:  0.000451902

p_wrong:  0.0084994

Data Source:  BioPlex

TPRA1

Tdark

Family:  GPCR

Novelty:  0.16743826

p_int:  0.966789374

p_ni:  0.025962657

p_wrong:  0.00724797

Score:  0.162

Data Source:  BioPlex,STRINGDB

CACNG1

Tbio

Family:  IC

Novelty:  0.11899252

p_int:  0.96317979

p_ni:  0.027472301

p_wrong:  0.009347909

Data Source:  BioPlex

APLNR

Tchem

Family:  GPCR

Novelty:  0.00224203

p_int:  0.96288607

p_ni:  0.035239602

p_wrong:  0.001874328

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (10)

KEGG (2)

PathwayCommons (1)

WikiPathways (1)

Asparagine N-linked glycosylation (R-HSA-446203)

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Find Similar Targets

Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	78 targets	R-HSA-446193
Reactome	Defective DOLK causes DOLK-CDG (CDG-1m)	1 targets	R-HSA-4755583
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases associated with glycosylation precursor biosynthesis	18 targets	R-HSA-5609975

Name	Explore in Pharos	Explore in Source
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	78 targets	R-HSA-446193
Defective DOLK causes DOLK-CDG (CDG-1m)	1 targets	R-HSA-4755583
Disease	1105 targets	R-HSA-1643685
Diseases associated with glycosylation precursor biosynthesis	18 targets	R-HSA-5609975

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Components (2)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
dolichol kinase activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
metabolite measurement	EFO_0004725	1	1	1		83.2
allergy	EFO_0003785	1	1	0	1.1	31.4
mean platelet volume	EFO_0004584	1	1	1		29

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
metabolite measurement	EFO_0004725	1		83.2
allergy	EFO_0003785	0	1.1	31.4
mean platelet volume	EFO_0004584	1		29

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Congenital disorder of glycosylation
Disease mutation
Endoplasmic reticulum
Kinase
Membrane
Polymorphism
Reference proteome
Transferase
Transmembrane

GWAS Trait Find Similar Targets

No Header	No Header
allergy
mean platelet volume
metabolite measurement

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
embryo phenotype
growth/size/body region phenotype
integument phenotype
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dolichol kinase	VGNC:4679	107976791
Macaque	dolichol kinase		717045
Mouse	dolichol kinase	MGI:2677836	227697
Rat	dolichol kinase	RGD:1310821	311847
Horse	dolichol kinase	VGNC:17278	100070129

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dolichol kinase
Macaque	dolichol kinase
Mouse	dolichol kinase
Rat	dolichol kinase
Horse	dolichol kinase

Publication Statistics

PubMed Score 157.00

PubMed score by year

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PubTator Score 7.64

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title