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Tbio
DOLK
Dolichol kinase

Protein Summary
Description
Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372586
  • ENSP00000361667
  • ENSG00000175283

Symbol
  • KIAA1094
  • TMEM15
  • DK
  • DK1
  • CDG1M
  • SEC59
  • TMEM15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.91
histone modification site profile
0.9
virus perturbation
0.9
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.82   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.82   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.999536341
p_ni:  0.000463026
p_wrong:  6.33e-7
Data Source:  BioPlex
KCNA6
Tclin
Family:  IC
Novelty:  18.19090909
p_int:  0.999343011
p_ni:  0.000528213
p_wrong:  0.000128776
Score:  0.234
Data Source:  BioPlex,STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.998829042
p_ni:  0.001084126
p_wrong:  0.000086833
Data Source:  BioPlex
CD274
Tclin
Novelty:  0.00013449
p_int:  0.996846914
p_ni:  0.003124411
p_wrong:  0.000028675
Data Source:  BioPlex
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.996482621
p_ni:  0.003154789
p_wrong:  0.000362589
Data Source:  BioPlex
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.995591599
p_ni:  0.004345223
p_wrong:  0.000063178
Score:  0.154
Data Source:  BioPlex,STRINGDB
KCNA5
Tclin
Family:  IC
Novelty:  0.00182891
p_int:  0.991048698
p_ni:  0.000451902
p_wrong:  0.0084994
Data Source:  BioPlex
TPRA1
Tbio
Family:  GPCR
Novelty:  0.16743826
p_int:  0.966789374
p_ni:  0.025962657
p_wrong:  0.00724797
Score:  0.162
Data Source:  BioPlex,STRINGDB
CACNG1
Tbio
Family:  IC
Novelty:  0.11899252
p_int:  0.96317979
p_ni:  0.027472301
p_wrong:  0.009347909
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.96288607
p_ni:  0.035239602
p_wrong:  0.001874328
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective DOLK causes DOLK-CDG (CDG-1m)
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective DOLK causes DOLK-CDG (CDG-1m)
Disease
Diseases associated with glycosylation precursor biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
1
4
92.7
nucleoside measurement
2
1
1
1.1
88.6
metabolite measurement
1
1
1
73.7
allergic disease
1
1
0
1.1
43.6
mean platelet volume
1
1
1
19.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
92.7
nucleoside measurement
1
1.1
88.6
metabolite measurement
1
73.7
allergic disease
0
1.1
43.6
mean platelet volume
1
19.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dolichol kinase
VGNC:4679
107976791
Macaque
dolichol kinase
717045
Mouse
MGI:2677836
227697
Rat
RGD:1310821
311847
Horse
dolichol kinase
VGNC:17278
100070129
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dolichol kinase
Macaque
dolichol kinase
Mouse
Rat
Horse
dolichol kinase
Publication Statistics
PubMed Score 236.82
PubMed score by year
PubTator Score 7.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title