Protein Summary
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
- ENST00000340099
- ENSP00000344277
- ENSG00000125170
- ENST00000569548
- ENSP00000455128
- IRS5
- IRS-5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.82 | ||
cell type or tissue | 0.62 | ||
gene perturbation | 0.62 | ||
tissue | 0.62 | ||
small molecule perturbation | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.49 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 221 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.49 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 221 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (70)
GSE1
Novelty: 0.04331197
p_int: 0.999952904
p_ni: 0.000047096
Score: 0.499
Data Source: BioPlex,STRINGDB
HMG20A
Family: TF
Novelty: 0.11994252
p_int: 0.999917729
p_ni: 0.000079812
p_wrong: 0.000002459
Score: 0.539
Data Source: BioPlex,STRINGDB
PHKA2
Family: Kinase
Novelty: 0.00461145
p_int: 0.999864351
p_ni: 0.0001356
p_wrong: 4.9e-8
Score: 0.734
Data Source: BioPlex,STRINGDB
PHKG2
Family: Kinase
Novelty: 0.064884
p_int: 0.999848918
p_ni: 0.000132883
p_wrong: 0.000018199
Score: 0.321
Data Source: BioPlex,STRINGDB
PHKB
Family: Enzyme
Novelty: 0.05506418
p_int: 0.999843217
p_ni: 0.000156584
p_wrong: 1.99e-7
Score: 0.613
Data Source: BioPlex,STRINGDB
PBK
Family: Kinase
Novelty: 0.00278659
p_int: 0.99967731
p_ni: 0.000322689
Score: 0.271
Data Source: BioPlex,STRINGDB
KBTBD7
Novelty: 0.4947466
p_int: 0.99963778
p_ni: 0.000362219
p_wrong: 1e-9
Data Source: BioPlex
AHCYL2
Family: Enzyme
Novelty: 0.08695339
p_int: 0.999237875
p_ni: 0.000762125
Data Source: BioPlex
KBTBD6
Novelty: 1.06955768
p_int: 0.997634375
p_ni: 0.002365625
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | RET signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
RET signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (2)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
CX3CL1 measurement | 1 | 1 | 1 | 86.9 | |||||
CCL17 measurement | 1 | 1 | 1 | 79.4 | |||||
blood protein measurement | 1 | 1 | 1 | 76.7 | |||||
eosinophil count | 1 | 1 | 1 | 52.7 | |||||
mosaic loss of chromosome Y measurement | 2 | 1 | 2 | 50.6 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
CX3CL1 measurement | 1 | 86.9 | |||||
CCL17 measurement | 1 | 79.4 | |||||
blood protein measurement | 1 | 76.7 | |||||
eosinophil count | 1 | 52.7 | |||||
mosaic loss of chromosome Y measurement | 2 | 50.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | docking protein 4 | VGNC:5750 | 454120 | |||||
Macaque | docking protein 4 | 704443 | ||||||
Mouse | MGI:2148865 | 114255 | ||||||
Rat | RGD:1310084 | 361364 | ||||||
Dog | docking protein 4 | VGNC:40058 | 487264 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | docking protein 4 | |||||
Macaque | docking protein 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | docking protein 4 | |||||
Publication Statistics
PubMed Score 17.49
PubMed score by year
PubTator Score 14.05
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
|---|