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Tbio
DOCK8
Dedicator of cytokinesis protein 8

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432829
  • ENSP00000394888
  • ENSG00000107099
  • ENST00000453981
  • ENSP00000408464
  • ENST00000469391
  • ENSP00000419438

Symbol
  • MRD2
  • ZIR8
  • HEL-205
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.85
kinase perturbation
0.81
transcription factor perturbation
0.8
histone modification site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.3   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.3   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
LRCH3
Tdark
Novelty:  1.02650989
p_int:  1
Score:  0.863
Data Source:  BioPlex,STRINGDB
LRCH1
Tbio
Novelty:  0.0923291
p_int:  0.999999997
p_ni:  2e-9
p_wrong:  2e-9
Score:  0.932
Data Source:  BioPlex,STRINGDB
LRCH2
Tdark
Novelty:  1.90908316
p_int:  0.999999881
p_ni:  1.19e-7
Score:  0.816
Data Source:  BioPlex,STRINGDB
LRCH4
Tbio
Novelty:  0.10751018
p_int:  0.99999985
p_ni:  1e-9
p_wrong:  1.49e-7
Score:  0.853
Data Source:  BioPlex,STRINGDB
DOCK7
Tbio
Novelty:  0.03425586
p_int:  0.999963249
p_ni:  0.000036751
Score:  0.704
Data Source:  BioPlex,STRINGDB
DOCK6
Tbio
Novelty:  0.01111596
p_int:  0.99992234
p_ni:  0.000077659
p_wrong:  1e-9
Score:  0.834
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.999834852
p_ni:  0.000165148
Score:  0.678
Data Source:  BioPlex,STRINGDB
APPBP2
Tbio
Novelty:  0.14742368
p_int:  0.999258425
p_ni:  0.000741575
Data Source:  BioPlex
CPNE7
Tbio
Novelty:  0.0748235
p_int:  0.89713991
p_ni:  0.057461024
p_wrong:  0.045399065
Score:  0.165
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
11
13
99.6
neutrophil count
3
3
3
93.2
myeloid white cell count
2
2
2
89.6
red blood cell distribution width
2
2
2
86.6
leukocyte count
2
2
2
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
13
99.6
neutrophil count
3
93.2
myeloid white cell count
2
89.6
red blood cell distribution width
2
86.6
leukocyte count
2
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921396
76088
Rat
RGD:1561588
499337
Dog
dedicator of cytokinesis 8
VGNC:40052
476333
Horse
dedicator of cytokinesis 8
VGNC:17269
100050677
Cow
dedicator of cytokinesis 8
VGNC:28162
100295817
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
dedicator of cytokinesis 8
Horse
dedicator of cytokinesis 8
Cow
dedicator of cytokinesis 8
Publication Statistics
PubMed Score 199.30
PubMed score by year
PubTator Score 108.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title