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Tbio
DOCK7
Dedicator of cytokinesis protein 7

Protein Summary
Description
Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251157
  • ENSP00000251157
  • ENSG00000116641
  • ENST00000340370
  • ENSP00000340742
  • ENST00000404627
  • ENSP00000384446
  • ENST00000454575
  • ENSP00000413583
  • ENST00000634264
  • ENSP00000489284
  • ENST00000635123
  • ENSP00000489499
  • ENST00000635253
  • ENSP00000489124

Symbol
  • KIAA1771
  • ZIR2
  • EIEE23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
trait
0.93
histone modification site profile
0.81
protein domain
0.73
cell line
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.97   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.97   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
LRCH1
Tbio
Novelty:  0.0923291
p_int:  0.999999657
p_ni:  3.43e-7
Score:  0.525
Data Source:  BioPlex,STRINGDB
LRCH3
Tdark
Novelty:  1.02650989
p_int:  0.999999533
p_ni:  4.67e-7
Score:  0.785
Data Source:  BioPlex,STRINGDB
DOCK8
Tbio
Novelty:  0.0067047
p_int:  0.999963249
p_ni:  0.000036751
Score:  0.704
Data Source:  BioPlex,STRINGDB
MOB1B
Tbio
Family:  Enzyme
Novelty:  0.0718959
p_int:  0.999698368
p_ni:  0.000301632
Score:  0.343
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.999460304
p_ni:  0.000539696
Score:  0.546
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.997231156
p_ni:  0.002768844
Data Source:  BioPlex
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.993589848
p_ni:  0.006410152
Data Source:  BioPlex
AVIL
Tbio
Novelty:  0.0175973
p_int:  0.99117639
p_ni:  0.00882361
Score:  0.168
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.97454735
p_ni:  0.02545265
Data Source:  BioPlex
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.945547955
p_ni:  0.054452045
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
MET activates RAP1 and RAC1
Reactome
MET promotes cell motility
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
MET activates RAP1 and RAC1
MET promotes cell motility
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
26
29
63
4.4
99.9
total cholesterol measurement
13
25
38
2.8
99.6
low density lipoprotein cholesterol measurement
9
17
26
2
99.1
apolipoprotein A 1 measurement
2
4
4
95.1
apolipoprotein B measurement
2
5
5
95
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
63
4.4
99.9
total cholesterol measurement
38
2.8
99.6
low density lipoprotein cholesterol measurement
26
2
99.1
apolipoprotein A 1 measurement
4
95.1
apolipoprotein B measurement
5
95
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 7
VGNC:10604
469340
Macaque
dedicator of cytokinesis 7
697028
Mouse
MGI:1914549
67299
Rat
RGD:1309790
313388
Dog
dedicator of cytokinesis 7
VGNC:40051
479548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 7
Macaque
dedicator of cytokinesis 7
Mouse
Rat
Dog
dedicator of cytokinesis 7
Publication Statistics
PubMed Score 31.97
PubMed score by year
PubTator Score 10.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title