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Tbio
DOCK6
Dedicator of cytokinesis protein 6

Protein Summary
Description
Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294618
  • ENSP00000294618
  • ENSG00000130158

Symbol
  • KIAA1395
  • AOS2
  • ZIR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.8
trait
0.75
cell line
0.7
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
LRCH3
Tdark
Novelty:  1.02650989
p_int:  1
Score:  0.831
Data Source:  BioPlex,STRINGDB
LRCH1
Tbio
Novelty:  0.0923291
p_int:  1
Score:  0.345
Data Source:  BioPlex,STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.999999465
p_ni:  5.3e-7
p_wrong:  5e-9
Data Source:  BioPlex
RRP9
Tbio
Novelty:  0.07232317
p_int:  0.999996815
p_ni:  0.000003185
Data Source:  BioPlex
DOCK8
Tbio
Novelty:  0.0067047
p_int:  0.99992234
p_ni:  0.000077659
p_wrong:  1e-9
Score:  0.834
Data Source:  BioPlex,STRINGDB
ZNF331
Tbio
Family:  TF
Novelty:  0.05976217
p_int:  0.980410163
p_ni:  0.019007847
p_wrong:  0.00058199
Score:  0.186
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.973
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.94
Data Source:  Reactome,STRINGDB
KANK2
Tbio
Novelty:  0.06232448
Score:  0.702
Data Source:  STRINGDB
EOGT
Tbio
Family:  Enzyme
Novelty:  0.08290891
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
21
25
33
3.8
99.8
low density lipoprotein cholesterol measurement
31
28
46
3
99.8
high density lipoprotein cholesterol measurement
50
17
65
10
99.6
apolipoprotein B measurement
4
15
16
96.8
reticulocyte count
7
6
11
96.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
33
3.8
99.8
low density lipoprotein cholesterol measurement
46
3
99.8
high density lipoprotein cholesterol measurement
65
10
99.6
apolipoprotein B measurement
16
96.8
reticulocyte count
11
96.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 6
VGNC:2393
455723
Macaque
dedicator of cytokinesis 6
716279
Mouse
MGI:1914789
319899
Rat
RGD:1306517
367039
Dog
dedicator of cytokinesis 6
VGNC:40050
611163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 6
Macaque
dedicator of cytokinesis 6
Mouse
Rat
Dog
dedicator of cytokinesis 6
Publication Statistics
PubMed Score 106.34
PubMed score by year
PubTator Score 36.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title