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Tbio
DOCK5
Dedicator of cytokinesis protein 5

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276440
  • ENSP00000276440
  • ENSG00000147459
  • ENST00000481100
  • ENSP00000429737
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
transcription factor perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.81
microRNA
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.38   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.38   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
ELMO1
Tbio
Novelty:  0.01598587
p_int:  1
Score:  0.892
Data Source:  BioPlex,STRINGDB
ELMO2
Tbio
Novelty:  0.04258272
p_int:  0.999999994
p_ni:  5e-9
Score:  0.895
Data Source:  BioPlex,STRINGDB
ZHX2
Tbio
Family:  TF
Novelty:  0.01370086
p_int:  0.999999992
p_ni:  2e-9
p_wrong:  6e-9
Score:  0.212
Data Source:  BioPlex,STRINGDB
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
p_int:  0.999999988
p_ni:  9e-9
p_wrong:  3e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
ELMO3
Tbio
Novelty:  0.05985405
p_int:  0.999998063
p_ni:  0.000001936
p_wrong:  1e-9
Score:  0.792
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999993427
p_ni:  0.000006572
Data Source:  BioPlex
ANKRD54
Tbio
Novelty:  0.03101679
p_int:  0.999620585
p_ni:  0.000001339
p_wrong:  0.000378076
Score:  0.219
Data Source:  BioPlex,STRINGDB
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.999539465
p_ni:  0.000460534
Data Source:  BioPlex
TGOLN2
Tbio
Novelty:  0.005107
p_int:  0.999099647
p_ni:  0.000226705
p_wrong:  0.000673648
Score:  0.152
Data Source:  BioPlex,STRINGDB
AHI1
Tbio
Novelty:  0.01180688
p_int:  0.998932259
p_ni:  0.000009728
p_wrong:  0.001058012
Score:  0.245
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
3
82.9
heel bone mineral density
2
2
2
76.7
reticulocyte measurement
3
2
3
70.4
testosterone measurement
2
2
2
66.6
lymphocyte count
2
1
2
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
82.9
heel bone mineral density
2
76.7
reticulocyte measurement
3
70.4
testosterone measurement
2
66.6
lymphocyte count
2
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 5
VGNC:888
464064
Macaque
dedicator of cytokinesis 5
711359
Mouse
MGI:2652871
68813
Rat
RGD:1306872
305987
Dog
dedicator of cytokinesis 5
VGNC:40049
100684965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 5
Macaque
dedicator of cytokinesis 5
Mouse
Rat
Dog
dedicator of cytokinesis 5
Publication Statistics
PubMed Score 36.38
PubMed score by year
PubTator Score 9.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title