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Tbio
DOCK4
Dedicator of cytokinesis protein 4

Protein Summary
Description
Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428084
  • ENSP00000410746
  • ENSG00000128512
  • ENST00000437633
  • ENSP00000404179

Symbol
  • KIAA0716
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
virus perturbation
0.96
transcription factor perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.14   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.14   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (358)
ELMO1
Tbio
Novelty:  0.01598587
p_int:  0.999999979
p_ni:  2.2e-8
Score:  0.93
Data Source:  BioPlex,STRINGDB
ELMO2
Tbio
Novelty:  0.04258272
p_int:  0.99999995
p_ni:  5e-8
Score:  0.953
Data Source:  BioPlex,STRINGDB
ELMO3
Tbio
Novelty:  0.05985405
p_int:  0.999996196
p_ni:  0.000003782
p_wrong:  2.3e-8
Score:  0.917
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999987049
p_ni:  0.000012951
Score:  0.955
Data Source:  BioPlex,STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
p_int:  0.999618081
p_ni:  0.000381918
Score:  0.189
Data Source:  BioPlex,STRINGDB
ERMAP
Tbio
Novelty:  0.04270359
p_int:  0.99945718
p_ni:  0.000542818
p_wrong:  2e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
p_int:  0.996759289
p_ni:  0.003238479
p_wrong:  0.000002232
Score:  0.321
Data Source:  BioPlex,STRINGDB
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.974412951
p_ni:  0.025580444
p_wrong:  0.000006605
Data Source:  BioPlex
MUL1
Tbio
Family:  Enzyme
Novelty:  0.00841786
p_int:  0.853339285
p_ni:  0.14666034
p_wrong:  3.75e-7
Data Source:  BioPlex
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.975
Data Source:  STRINGDB
Pathways (6)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

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Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
HGNC
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
52.7
leukocyte count
1
1
1
46.1
C-reactive protein measurement
1
1
1
46.1
serum albumin measurement
1
1
1
42.3
sex hormone-binding globulin measurement
2
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
52.7
leukocyte count
1
46.1
C-reactive protein measurement
1
46.1
serum albumin measurement
1
42.3
sex hormone-binding globulin measurement
2
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 4
VGNC:4333
463661
Macaque
dedicator of cytokinesis 4
703726
Mouse
MGI:1918006
238130
Rat
RGD:1561724
366608
Dog
dedicator of cytokinesis 4
VGNC:40048
482407
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 4
Macaque
dedicator of cytokinesis 4
Mouse
Rat
Dog
dedicator of cytokinesis 4
Publication Statistics
PubMed Score 46.14
PubMed score by year
PubTator Score 35.79
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title