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Tdark
DOCK11
Dedicator of cytokinesis protein 11

Protein Summary
Description
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276202
  • ENSP00000276202
  • ENSG00000147251

Symbol
  • ZIZ2
  • ACG
  • ZIZ2
  • bB128O4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
tissue
0.61
transcription factor perturbation
0.61
histone modification site profile
0.56
PubMedID
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.57   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.57   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
C10orf88
Tdark
Novelty:  0.49807003
p_int:  0.999999924
p_ni:  6.5e-8
p_wrong:  1.1e-8
Data Source:  BioPlex
DENR
Tbio
Novelty:  0.00653432
p_int:  0.999999477
p_ni:  5.23e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
UQCRH
Tbio
Novelty:  0.04494433
p_int:  0.999984407
p_ni:  0.000015593
Score:  0.173
Data Source:  BioPlex,STRINGDB
ARHGAP22
Tbio
Family:  Enzyme
Novelty:  0.13037853
p_int:  0.994865463
p_ni:  0.004219409
p_wrong:  0.000915127
Score:  0.26
Data Source:  BioPlex,STRINGDB
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.992320455
p_ni:  0.007679474
p_wrong:  7.1e-8
Data Source:  BioPlex
GCHFR
Tbio
Family:  Enzyme
Novelty:  0.04287433
p_int:  0.954657932
p_ni:  0.045341644
p_wrong:  4.24e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.979
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.939
Data Source:  Reactome,STRINGDB
GAA
Tclin
Family:  Enzyme
Novelty:  0.0063246
Score:  0.882
Data Source:  STRINGDB
AGA
Tbio
Family:  Enzyme
Novelty:  0.01522819
Score:  0.863
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
80.3
1
1
0
1.1
62.1
mean platelet volume
1
1
1
61.4
sex hormone-binding globulin measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
80.3
0
1.1
62.1
mean platelet volume
1
61.4
sex hormone-binding globulin measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 11
VGNC:1392
465822
Macaque
dedicator of cytokinesis 11
710690
Mouse
MGI:1923224
75974
Rat
RGD:1564707
313438
Dog
dedicator of cytokinesis 11
VGNC:40045
492089
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dedicator of cytokinesis 11
Macaque
dedicator of cytokinesis 11
Mouse
Rat
Dog
dedicator of cytokinesis 11
Publication Statistics
PubMed Score 35.57
PubMed score by year
PubTator Score 6.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title