Tbio DOC2A Double C2-like domain-containing protein alpha

Protein Summary

Description

Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q14183
• B4DEJ2
• H3BNH6
• Q6P4G4
• Q7Z5G0
• Q8IVX0
• Doc2

Gene Name

• DOC2A

Ensembl ID

• ENST00000350119
• ENSP00000340017
• ENSG00000149927
• ENST00000564944
• ENSP00000455196
• ENST00000564979
• ENSP00000455624
• ENST00000566310
• ENSP00000454857
• ENST00000616445
• ENSP00000482870

Symbol

• Doc2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.66
histone modification site profile	0.63
gene perturbation	0.59
PubMedID	0.56
molecular function	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.62   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.62   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (70)

Explore Interacting Targets

1 – 10 of 70

• See Interactions on String-DB

DOC2B

Tbio

Novelty:  0.05460532

p_int:  0.999999563

p_wrong:  4.36e-7

Score:  0.499

Data Source:  BioPlex,STRINGDB

TTC21B

Tbio

Novelty:  0.02480259

p_int:  0.999995287

p_ni:  0.000004713

Score:  0.534

Data Source:  BioPlex,STRINGDB

KCTD21

Tbio

Novelty:  1.05252269

p_int:  0.999988799

p_ni:  0.000011164

p_wrong:  3.7e-8

Score:  0.28

Data Source:  BioPlex,STRINGDB

SCGN

Tbio

Novelty:  0.01434518

p_int:  0.999935279

p_ni:  0.000064721

Score:  0.248

Data Source:  BioPlex,STRINGDB

UBASH3B

Tbio

Novelty:  0.02155898

p_int:  0.999910166

p_ni:  0.000035613

p_wrong:  0.000054221

Score:  0.332

Data Source:  BioPlex,STRINGDB

GPR137B

Tbio

Novelty:  0.17325252

p_int:  0.999607487

p_ni:  0.000392512

p_wrong:  1e-9

Score:  0.227

Data Source:  BioPlex,STRINGDB

SETMAR

Tbio

Family:  Epigenetic

Novelty:  0.02859547

p_int:  0.934085799

p_ni:  0.000135616

p_wrong:  0.065778585

Score:  0.214

Data Source:  BioPlex,STRINGDB

SNAP25

Tclin

Novelty:  0.00148905

Score:  0.852

Data Source:  STRINGDB

SEZ6L2

Tbio

Novelty:  0.02623263

Score:  0.782

Data Source:  STRINGDB

ASPHD1

Tdark

Family:  Enzyme

Novelty:  0.97195692

Score:  0.772

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (2)

Components (6)

Processes (4)

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GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro
calcium-dependent phospholipid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (49)

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5

1 – 5 of 49

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	6	5	6		96.4
appendicular lean mass	EFO_0004980	2	3	6		94.7
mean corpuscular volume	EFO_0004526	3	2	3		94
waist-hip ratio	EFO_0004343	3	3	3		89.1
red blood cell density measurement	EFO_0007978	2	1	2		87.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 49

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	6		96.4
appendicular lean mass	EFO_0004980	6		94.7
mean corpuscular volume	EFO_0004526	3		94
waist-hip ratio	EFO_0004343	3		89.1
red blood cell density measurement	EFO_0007978	2		87.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calcium
Calcium/phospholipid-binding
Cell junction
Complete proteome
Cytoplasmic vesicle
Exocytosis
Lysosome
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
Agents acting on the renin-angiotensin system use measurement
alcohol consumption measurement
alcohol use disorder measurement
anxiety measurement
apolipoprotein A 1 measurement
appendicular lean mass
autism spectrum disorder
bipolar disorder
BMI-adjusted waist circumference

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	double C2 domain alpha		707895
Mouse	double C2, alpha	MGI:109446	13446
Rat	double C2 domain alpha	RGD:620518	65031
Dog	double C2 domain alpha	VGNC:40042	489945
Horse	double C2 domain alpha	VGNC:17262	100066024

Species	Name	OMA	EggNOG	Inparanoid
Macaque	double C2 domain alpha
Mouse	double C2, alpha
Rat	double C2 domain alpha
Dog	double C2 domain alpha
Horse	double C2 domain alpha

Publication Statistics

PubMed Score 13.62

PubMed score by year

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PubTator Score 29.70

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (4)

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PMID	Year	Title