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Tbio
DOC2A
Double C2-like domain-containing protein alpha

Protein Summary
Description
Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350119
  • ENSP00000340017
  • ENSG00000149927
  • ENST00000564944
  • ENSP00000455196
  • ENST00000564979
  • ENSP00000455624
  • ENST00000566310
  • ENSP00000454857
  • ENST00000616445
  • ENSP00000482870

Symbol
  • Doc2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.66
histone modification site profile
0.63
gene perturbation
0.59
PubMedID
0.56
molecular function
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.62   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.62   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
DOC2B
Tbio
Novelty:  0.05460532
p_int:  0.999999563
p_wrong:  4.36e-7
Score:  0.499
Data Source:  BioPlex,STRINGDB
TTC21B
Tbio
Novelty:  0.02480259
p_int:  0.999995287
p_ni:  0.000004713
Score:  0.534
Data Source:  BioPlex,STRINGDB
KCTD21
Tbio
Novelty:  1.05252269
p_int:  0.999988799
p_ni:  0.000011164
p_wrong:  3.7e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.999935279
p_ni:  0.000064721
Score:  0.248
Data Source:  BioPlex,STRINGDB
UBASH3B
Tbio
Novelty:  0.02155898
p_int:  0.999910166
p_ni:  0.000035613
p_wrong:  0.000054221
Score:  0.332
Data Source:  BioPlex,STRINGDB
GPR137B
Tbio
Novelty:  0.17325252
p_int:  0.999607487
p_ni:  0.000392512
p_wrong:  1e-9
Score:  0.227
Data Source:  BioPlex,STRINGDB
SETMAR
Tbio
Family:  Epigenetic
Novelty:  0.02859547
p_int:  0.934085799
p_ni:  0.000135616
p_wrong:  0.065778585
Score:  0.214
Data Source:  BioPlex,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.852
Data Source:  STRINGDB
SEZ6L2
Tbio
Novelty:  0.02623263
Score:  0.782
Data Source:  STRINGDB
ASPHD1
Tdark
Family:  Enzyme
Novelty:  0.97195692
Score:  0.772
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
5
6
96.4
appendicular lean mass
2
3
6
94.7
mean corpuscular volume
3
2
3
94
waist-hip ratio
3
3
3
89.1
red blood cell density measurement
2
1
2
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
96.4
appendicular lean mass
6
94.7
mean corpuscular volume
3
94
waist-hip ratio
3
89.1
red blood cell density measurement
2
87.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
double C2 domain alpha
707895
Mouse
MGI:109446
13446
Rat
RGD:620518
65031
Dog
double C2 domain alpha
VGNC:40042
489945
Horse
double C2 domain alpha
VGNC:17262
100066024
Species
Name
OMA
EggNOG
Inparanoid
Macaque
double C2 domain alpha
Mouse
Rat
Dog
double C2 domain alpha
Horse
double C2 domain alpha
Publication Statistics
PubMed Score 13.62
PubMed score by year
PubTator Score 29.70
PubTator score by year
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Related Publications
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PMID
Year
Title