Tbio DOC2A Double C2-like domain-containing protein alpha

Protein Summary

Description

Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q14183
• B4DEJ2
• H3BNH6
• Q6P4G4
• Q7Z5G0
• Q8IVX0
• Doc2

Gene Name

• DOC2A

Ensembl ID

• ENST00000350119
• ENSP00000340017
• ENSG00000149927
• ENST00000564944
• ENSP00000455196
• ENST00000564979
• ENSP00000455624
• ENST00000566310
• ENSP00000454857
• ENST00000616445
• ENSP00000482870

Symbol

• Doc2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.66
histone modification site profile	0.63
gene perturbation	0.59
PubMedID	0.56
molecular function	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.25   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.25   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0