Protein Summary
Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism. The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
- ENST00000273075
- ENSP00000273075
- ENSG00000123992
- ASPEP
- DAP
- DAP
- ASPEP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 0.97 | ||
co-expressed gene | 0.94 | ||
histone modification site profile | 0.8 | ||
transcription factor | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.94 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 183 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.94 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 183 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (53)
RAB11B
Family: Enzyme
Novelty: 0.00557558
p_int: 0.999969764
p_ni: 0.000030174
p_wrong: 6.2e-8
Score: 0.199
Data Source: BioPlex,STRINGDB
RAB11A
Family: Enzyme
Novelty: 0.00153551
p_int: 0.999890205
p_ni: 0.000109795
Score: 0.203
Data Source: BioPlex,STRINGDB
TAF15
Novelty: 0.0621505
p_int: 0.999158423
p_ni: 0.000841577
Score: 0.269
Data Source: BioPlex,STRINGDB
MPPED1
Family: Enzyme
Novelty: 0.58103321
p_int: 0.9943934
p_ni: 0.005606599
Score: 0.198
Data Source: BioPlex,STRINGDB
SCAF8
Novelty: 0.1650699
p_int: 0.993048658
p_ni: 0.00694506
p_wrong: 0.000006282
Score: 0.199
Data Source: BioPlex,STRINGDB
ANKRD39
Novelty: 8.68843298
p_int: 0.986171935
p_ni: 0.013828016
p_wrong: 4.9e-8
Data Source: BioPlex
LGALS13
Novelty: 0.00695816
p_int: 0.959026035
p_ni: 0.040973692
p_wrong: 2.74e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
MSMB
Novelty: 0.00241546
p_int: 0.792510232
p_ni: 0.207456602
p_wrong: 0.000033166
Data Source: BioPlex
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Ciliary landscape | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ciliary landscape | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (4)
Components (5)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 3 | 2 | 3 | 84.7 | |||||
electrocardiography | 1 | 1 | 82 | 75.9 | |||||
reticulocyte count | 2 | 1 | 2 | 71.3 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 68.8 | |||||
creatinine measurement | 1 | 1 | 1 | 63.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 3 | 84.7 | |||||
electrocardiography | 82 | 75.9 | |||||
reticulocyte count | 2 | 71.3 | |||||
mean reticulocyte volume | 1 | 68.8 | |||||
creatinine measurement | 1 | 63.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aspartyl aminopeptidase | VGNC:168 | 459964 | |||||
Macaque | aspartyl aminopeptidase | 703180 | ||||||
Mouse | MGI:1278328 | 13437 | ||||||
Rat | RGD:1583848 | 301529 | ||||||
Dog | aspartyl aminopeptidase | VGNC:40038 | 478922 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aspartyl aminopeptidase | |||||
Macaque | aspartyl aminopeptidase | |||||
Mouse | ||||||
Rat | ||||||
Dog | aspartyl aminopeptidase | |||||
Publication Statistics
PubMed Score 41.94
PubMed score by year
PubTator Score 6.61
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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