DNMT3L
DNA (cytosine-5)-methyltransferase 3-like
Protein Summary
Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an ...more
- ENST00000270172
- ENSP00000270172
- ENSG00000142182
- ENST00000628202
- ENSP00000486001
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.76 | ||
kinase perturbation | 0.66 | ||
PubMedID | 0.63 | ||
biological process | 0.58 | ||
cell type or tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.5 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 536 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.5 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 536 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (98)
Nearest Tclin Targets
Pathways (19)
Reactome (3)
WikiPathways (16)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | DNA methylation | ||||
Reactome | Epigenetic regulation of gene expression | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA methylation | ||||
Epigenetic regulation of gene expression | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (2)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 3 | 0 | 1.1 | 90.1 | |||||
Addison disease | 1 | 2 | 0 | 2.8 | 88.2 | ||||
eosinophil count | 3 | 2 | 3 | 85.1 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 82.2 | |||||
1 | 1 | 0 | 1.1 | 77.7 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 90.1 | |||||
Addison disease | 0 | 2.8 | 88.2 | ||||
eosinophil count | 3 | 85.1 | |||||
eosinophil percentage of leukocytes | 2 | 82.2 | |||||
0 | 1.1 | 77.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DNA methyltransferase 3 like | VGNC:14661 | 470099 | |||||
Macaque | DNA methyltransferase 3 like | 722184 | ||||||
Mouse | MGI:1859287 | 54427 | ||||||
Rat | RGD:1303239 | 309680 | ||||||
Dog | DNA methyltransferase 3 like | 608536 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DNA methyltransferase 3 like | |||||
Macaque | DNA methyltransferase 3 like | |||||
Mouse | ||||||
Rat | ||||||
Dog | DNA methyltransferase 3 like | |||||
Publication Statistics
PubMed Score 124.50
PubMed score by year
PubTator Score 63.51
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
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