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Tclin
DNMT1
DNA (cytosine-5)-methyltransferase 1

Protein Summary
Description
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to mainta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340748
  • ENSP00000345739
  • ENSG00000130816
  • ENST00000359526
  • ENSP00000352516

Symbol
  • AIM
  • CXXC9
  • DNMT
  • AIM
  • DNMT
  • MCMT
  • CXXC9
  • HSN1E
  • ADCADN
  • m.HsaI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.93
chemical
0.92
kinase
0.92
biological process
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3028.83   (req: < 5)
Gene RIFs: 449   (req: <= 3)
Antibodies: 1477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3028.83   (req: >= 5)
Gene RIFs: 449   (req: > 3)
Antibodies: 1477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 81
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2