Tchem DNM2 Dynamin-2

Protein Summary

Description

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P50570
• A8K1B6
• E7EV30
• E9PEQ4
• K7ESI9
• Q5I0Y0
• Q7Z5S3
• Q9UPH4

Gene Name

• DNM2

Ensembl ID

• ENST00000355667
• ENSP00000347890
• ENSG00000079805
• ENST00000359692
• ENSP00000352721
• ENST00000389253
• ENSP00000373905
• ENST00000408974
• ENSP00000386192
• ENST00000585892
• ENSP00000468734

Symbol

• DYN2
• DYN2
• CMT2M
• DYNII
• LCCS5
• CMTDI1
• CMTDIB
• DI-CMTB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
protein domain	1
molecular function	0.98
hub protein	0.94
biological process	0.9

Protein Classes

PANTHER Classes

Protein / Hydrolase / Dynamin-2

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-2

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Dynamin-2

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 415.3   (req: < 5)

Gene RIFs: 106   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 415.3   (req: >= 5)

Gene RIFs: 106   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (3)

Explore Active Ligands

1 – 3 of 3

CHEMBL1094197

DNM2Tchem

pIC50 : 6.54

CHEMBL1098764

DNM2Tchem

pIC50 : 6.41

CHEMBL1094850

DNM2Tchem

pIC50 : 6.36

Protein-Protein Interactions (334)

Explore Interacting Targets

1 – 10 of 334

• See Interactions on String-DB

DNM1

Tbio

Novelty:  0.00319082

p_int:  0.999999766

p_ni:  2.34e-7

Score:  0.905

Data Source:  BioPlex,STRINGDB

SH3D19

Tbio

Novelty:  0.05352867

p_int:  0.999991744

p_ni:  0.000006584

p_wrong:  0.000001672

Score:  0.399

Data Source:  BioPlex,STRINGDB

ACTA1

Tbio

Novelty:  0.00111813

p_int:  0.999949265

p_ni:  0.000050735

Score:  0.447

Data Source:  BioPlex,STRINGDB

GRB2

Tchem

Novelty:  0.00091605

p_int:  0.999940946

p_ni:  0.000059054

Score:  0.975

Data Source:  BioPlex,STRINGDB

DNMBP

Tbio

Novelty:  0.0533946

p_int:  0.999848614

p_ni:  0.000151222

p_wrong:  1.64e-7

Score:  0.556

Data Source:  BioPlex,STRINGDB

DNM3

Tbio

Novelty:  0.02365643

p_int:  0.999702388

p_ni:  0.00029761

p_wrong:  2e-9

Score:  0.982

Data Source:  BioPlex,STRINGDB

TMEM9

Tbio

Novelty:  0.06916197

p_int:  0.997667697

p_ni:  0.002332303

Data Source:  BioPlex

PCDHGB2

Tdark

Novelty:  1.16587709

p_int:  0.995070269

p_ni:  0.004929242

p_wrong:  4.89e-7

Data Source:  BioPlex

TYROBP

Tbio

Family:  Enzyme

Novelty:  0.00410031

p_int:  0.990984016

p_ni:  0.009015984

Data Source:  BioPlex

IKBIP

Tbio

Family:  Enzyme

Novelty:  0.18707639

p_int:  0.990725941

p_ni:  0.00927221

p_wrong:  0.00000185

Data Source:  BioPlex

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Upstream (1)

1 – 1 of 1

SRC

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  2

1: Endocytosis

2: Bacterial invasion of epithelial cells

Pathways (46)

Reactome (28)

KEGG (6)

PathwayCommons (10)

WikiPathways (2)

Adaptive Immune System (R-HSA-1280218)

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5

1 – 5 of 28

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Formation of annular gap junctions	9 targets	R-HSA-196025

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Axon guidance	533 targets	R-HSA-422475
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Developmental Biology	1055 targets	R-HSA-1266738
Formation of annular gap junctions	9 targets	R-HSA-196025

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (90)

Functions (11)

Components (36)

Processes (43)

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10

1 – 10 of 11

GO Term	Evidence	Assigned by
SH3 domain binding	Inferred from Direct Assay (IDA)	UniProtKB
GTPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
microtubule binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
enzyme binding	Non-traceable Author Statement (NAS)	UniProtKB
GTP binding	Non-traceable Author Statement (NAS)	UniProtKB
D2 dopamine receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl
nitric-oxide synthase binding	Inferred from Electronic Annotation (IEA)	Ensembl
phosphatidylinositol 3-kinase regulatory subunit binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein-containing complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (21)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	2	8	9		99
apolipoprotein B measurement	EFO_0004615	1	6	6		98.6
total cholesterol measurement	EFO_0004574	2	7	8		98.5
body height	EFO_0004339	3	4	4		95.7
reticulocyte measurement	EFO_0010700	3	2	3		94.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	9		99
apolipoprotein B measurement	EFO_0004615	6		98.6
total cholesterol measurement	EFO_0004574	8		98.5
body height	EFO_0004339	4		95.7
reticulocyte measurement	EFO_0010700	3		94.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell junction
Cell membrane
Cell projection
Charcot-Marie-Tooth disease
Coated pit
Complete proteome
Cytoplasm

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
BMI-adjusted hip circumference
body height
C-reactive protein measurement
chronotype measurement
forced expiratory volume
IGF-1 measurement
lifestyle measurement
low density lipoprotein cholesterol measurement
mean corpuscular volume

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dynamin 2	VGNC:2394	455718
Macaque	dynamin 2		713558
Mouse	dynamin 2	MGI:109547	13430
Rat	dynamin 2	RGD:2513	25751
Dog	dynamin 2	VGNC:40033	484949

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dynamin 2
Macaque	dynamin 2
Mouse	dynamin 2
Rat	dynamin 2
Dog	dynamin 2

Publication Statistics

PubMed Score 415.30

PubMed score by year

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PubTator Score 280.59

PubTator score by year

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Related Publications

Text Mined References (164)

GeneRif Annotations (106)

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PMID	Year	Title