Protein Summary
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cyt ...more
- ENST00000355667
- ENSP00000347890
- ENSG00000079805
- ENST00000359692
- ENSP00000352721
- ENST00000389253
- ENSP00000373905
- ENST00000408974
- ENSP00000386192
- ENST00000585892
- ENSP00000468734
- DYN2
- DYN2
- CMT2M
- DYNII
- LCCS5
- CMTDI1
- CMTDIB
- DI-CMTB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein complex | 1 | ||
protein domain | 1 | ||
molecular function | 0.98 | ||
hub protein | 0.94 | ||
biological process | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 415.3 (req: < 5)
Gene RIFs: 106 (req: <= 3)
Antibodies: 213 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 415.3 (req: >= 5)
Gene RIFs: 106 (req: > 3)
Antibodies: 213 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 54
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (334)
DNM1
Novelty: 0.00319082
p_int: 0.999999766
p_ni: 2.34e-7
Score: 0.905
Data Source: BioPlex,STRINGDB
SH3D19
Novelty: 0.05352867
p_int: 0.999991744
p_ni: 0.000006584
p_wrong: 0.000001672
Score: 0.399
Data Source: BioPlex,STRINGDB
ACTA1
Novelty: 0.00111813
p_int: 0.999949265
p_ni: 0.000050735
Score: 0.447
Data Source: BioPlex,STRINGDB
GRB2
Novelty: 0.00091605
p_int: 0.999940946
p_ni: 0.000059054
Score: 0.975
Data Source: BioPlex,STRINGDB
DNMBP
Novelty: 0.0533946
p_int: 0.999848614
p_ni: 0.000151222
p_wrong: 1.64e-7
Score: 0.556
Data Source: BioPlex,STRINGDB
DNM3
Novelty: 0.02365643
p_int: 0.999702388
p_ni: 0.00029761
p_wrong: 2e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
PCDHGB2
Novelty: 1.16587709
p_int: 0.995070269
p_ni: 0.004929242
p_wrong: 4.89e-7
Data Source: BioPlex
TYROBP
Family: Enzyme
Novelty: 0.00410031
p_int: 0.990984016
p_ni: 0.009015984
Data Source: BioPlex
IKBIP
Family: Enzyme
Novelty: 0.18707639
p_int: 0.990725941
p_ni: 0.00927221
p_wrong: 0.00000185
Data Source: BioPlex
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (46)
Reactome (28)
KEGG (6)
PathwayCommons (10)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Axon guidance | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Developmental Biology | ||||
Reactome | Formation of annular gap junctions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Axon guidance | ||||
Clathrin-mediated endocytosis | ||||
Developmental Biology | ||||
Formation of annular gap junctions | ||||
Viral Interactions (0)
Gene Ontology Terms (90)
Functions (11)
Components (36)
Processes (43)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 2 | 8 | 9 | 99 | |||||
apolipoprotein B measurement | 1 | 6 | 6 | 98.6 | |||||
total cholesterol measurement | 2 | 7 | 8 | 98.5 | |||||
body height | 3 | 4 | 4 | 95.7 | |||||
reticulocyte measurement | 3 | 2 | 3 | 94.6 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 9 | 99 | |||||
apolipoprotein B measurement | 6 | 98.6 | |||||
total cholesterol measurement | 8 | 98.5 | |||||
body height | 4 | 95.7 | |||||
reticulocyte measurement | 3 | 94.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | dynamin 2 | VGNC:2394 | 455718 | |||||
Macaque | dynamin 2 | 713558 | ||||||
Mouse | MGI:109547 | 13430 | ||||||
Rat | RGD:2513 | 25751 | ||||||
Dog | dynamin 2 | VGNC:40033 | 484949 | |||||
Publication Statistics
PubMed Score 415.30
PubMed score by year
PubTator Score 280.59
PubTator score by year
Related Publications
Text Mined References (164)
GeneRif Annotations (106)
Items per page:
0 of 0
PMID | Year | Title |
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