You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
DNLZ
DNL-type zinc finger protein

Protein Summary
Description
May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371738
  • ENSP00000360803
  • ENSG00000213221

Symbol
  • C9orf151
  • HEP
  • HEP1
  • ZIM17
  • TIMM15
  • C9orf151
  • bA413M3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.73
transcription factor binding site profile
0.63
transcription factor perturbation
0.61
tissue sample
0.54
tissue
0.47


Protein Classes
 No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.8   (req: < 5)
View Publications
Gene RIFs: 3   (req: <= 3)
View Gene RIFs
Antibodies: 5   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.8   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
 No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
Go To Tool
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
Go To Tool
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
Go To Tool
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Go To Tool
Approved Drugs (0)
 No approved drugs found
Active Ligands (0)
 No active ligands found
Protein-Protein Interactions (63)
1 – 10 of 63
ADIPOQ
Tbio
Novelty:  0.00011196
p_int:  0.999950618
p_ni:  0.00004938
p_wrong:  2e-9
Data Source:  BioPlex
CCL14
Tbio
Novelty:  0.0103752
p_int:  0.999924472
p_ni:  0.000075528
Score:  0.189
Data Source:  BioPlex,STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
p_int:  0.996957121
p_ni:  0.003042259
p_wrong:  6.2e-7
Score:  0.946
Data Source:  BioPlex,STRINGDB
SERPINB11
Tbio
Novelty:  0.09937169
p_int:  0.995874927
p_ni:  0.004125054
p_wrong:  1.9e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
ISOC2
Tbio
Family:  Enzyme
Novelty:  0.33841868
p_int:  0.995151512
p_ni:  0.004847814
p_wrong:  6.74e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
SUCLA2
Tchem
Family:  Enzyme
Novelty:  0.02029861
p_int:  0.991606287
p_ni:  0.008393336
p_wrong:  3.76e-7
Data Source:  BioPlex
ATPAF2
Tbio
Family:  Enzyme
Novelty:  0.04184643
p_int:  0.987182986
p_ni:  0.012816851
p_wrong:  1.63e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
LDHAL6B
Tbio
Family:  Enzyme
Novelty:  0.00801753
p_int:  0.982796594
p_ni:  0.017163412
p_wrong:  0.000039995
Score:  0.265
Data Source:  BioPlex,STRINGDB
ECHDC2
Tdark
Family:  Enzyme
Novelty:  0.50396935
p_int:  0.982476744
p_ni:  0.017523253
p_wrong:  3e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
SLC25A22
Tbio
Family:  Transporter
Novelty:  0.05854569
p_int:  0.982301948
p_ni:  0.017698044
p_wrong:  8e-9
Score:  0.279
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
 Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
 No pathways found
Viral Interactions (0)
 No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
chaperone binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
zinc ion binding
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
 No disease associations found
GWAS Traits (39)
Items per page:
1 – 5 of 39
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type II diabetes mellitus
EFO_0001360
14
10
4
1.1
98.8
Crohn's disease
EFO_0000384
3
3
1
1.2
94.9
HbA1c measurement
EFO_0004541
3
3
3
94.5
leukocyte count
EFO_0004308
3
3
3
92.1
ulcerative colitis
EFO_0000729
4
3
1
1.1
91.4
Items per page:
1 – 5 of 39
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type II diabetes mellitus
EFO_0001360
4
1.1
98.8
Crohn's disease
EFO_0000384
1
1.2
94.9
HbA1c measurement
EFO_0004541
3
94.5
leukocyte count
EFO_0004308
3
92.1
ulcerative colitis
EFO_0000729
1
1.1
91.4
Find similar targets by:
IDG Resources
 No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNL-type zinc finger
VGNC:13869
464857
Macaque
DNL-type zinc finger
721763
Mouse
DNL-type zinc finger
MGI:106559
52838
Rat
DNL-type zinc finger
RGD:1308635
296587
Dog
DNL-type zinc finger
VGNC:40031
607502
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNL-type zinc finger
Macaque
DNL-type zinc finger
Mouse
DNL-type zinc finger
Rat
DNL-type zinc finger
Dog
DNL-type zinc finger
Publication Statistics
PubMed Score 10.80
PubMed score by year
PubTator Score 174.58
PubTator score by year
Related Publications
Items per page:
0 of 0
PMID
Year
Title