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Tbio
DND1
Dead end protein homolog 1

Protein Summary
Description
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000542735
  • ENSP00000445366
  • ENSG00000256453

Symbol
  • RBMS4
  • RBMS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.62
cell type or tissue
0.57
transcription factor perturbation
0.54
phenotype
0.43
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.81   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.81   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
ATXN3
Tbio
Novelty:  0.00201109
p_int:  0.999412306
p_ni:  0.000028795
p_wrong:  0.000558899
Score:  0.269
Data Source:  BioPlex,STRINGDB
PAIP2B
Tbio
Novelty:  0.65592664
p_int:  0.998857689
p_ni:  0.001139862
p_wrong:  0.000002449
Score:  0.228
Data Source:  BioPlex,STRINGDB
RALGAPB
Tbio
Family:  Enzyme
Novelty:  0.31941838
p_int:  0.989706682
p_ni:  0.010293314
p_wrong:  4e-9
Score:  0.261
Data Source:  BioPlex,STRINGDB
EMB
Tbio
Novelty:  0.00135577
p_int:  0.982860689
p_ni:  0.003706775
p_wrong:  0.013432536
Score:  0.188
Data Source:  BioPlex,STRINGDB
VCPIP1
Tbio
Novelty:  0.09915033
p_int:  0.981358066
p_ni:  0.018641934
Score:  0.196
Data Source:  BioPlex,STRINGDB
ACTR3C
Tdark
Novelty:  0.16443513
p_int:  0.908692266
p_ni:  0.000020041
p_wrong:  0.091287693
Score:  0.324
Data Source:  BioPlex,STRINGDB
NANOS3
Tbio
Novelty:  0.02275038
Score:  0.88
Data Source:  STRINGDB
DAZL
Tbio
Novelty:  0.00421428
Score:  0.857
Data Source:  STRINGDB
TDRD7
Tbio
Family:  Epigenetic
Novelty:  0.03580848
Score:  0.788
Data Source:  STRINGDB
NANOS1
Tbio
Novelty:  0.02855732
Score:  0.738
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Breast cancer pathway
Name
Explore in Pharos
Explore in Source
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
Breast cancer pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
3
1
5.9
56.4
self reported educational attainment
2
2
2
45.2
household income
1
1
1
24.5
cognitive function measurement
3
1
3
24.5
systolic blood pressure
1
1
1
24.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
5.9
56.4
self reported educational attainment
2
45.2
household income
1
24.5
cognitive function measurement
3
24.5
systolic blood pressure
1
24.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DND microRNA-mediated repression inhibitor 1
VGNC:11933
462121
Mouse
MGI:2447763
213236
Rat
RGD:1583648
679841
Dog
DND microRNA-mediated repression inhibitor 1
VGNC:40028
607141
Horse
DND microRNA-mediated repression inhibitor 1
VGNC:17250
100061778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DND microRNA-mediated repression inhibitor 1
Mouse
Rat
Dog
DND microRNA-mediated repression inhibitor 1
Horse
DND microRNA-mediated repression inhibitor 1
Publication Statistics
PubMed Score 37.81
PubMed score by year
PubTator Score 13.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title