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Tbio
DNASE1L2
Deoxyribonuclease-1-like 2

Protein Summary
Description
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320700
  • ENSP00000316938
  • ENSG00000167968
  • ENST00000382437
  • ENSP00000371874
  • ENST00000564065
  • ENSP00000454562
  • ENST00000567494
  • ENSP00000455358
  • ENST00000613572
  • ENSP00000482627

Symbol
  • DHP1
  • DNAS1L2
  • DNAS1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.67
cell type or tissue
0.66
phenotype
0.59
tissue sample
0.59
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.13   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.13   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
INKA2
Tdark
Novelty:  0.57898295
p_int:  0.99985646
p_ni:  0.000143533
p_wrong:  7e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
SLC19A2
Tbio
Family:  Transporter
Novelty:  0.00761796
p_int:  0.982694912
p_ni:  0.017216668
p_wrong:  0.00008842
Score:  0.204
Data Source:  BioPlex,STRINGDB
SLC25A21
Tbio
Family:  Transporter
Novelty:  0.15355545
p_int:  0.978605273
p_ni:  0.021393925
p_wrong:  8.02e-7
Score:  0.822
Data Source:  BioPlex,STRINGDB
PHF13
Tbio
Family:  Epigenetic
Novelty:  0.02577645
p_int:  0.978605273
p_ni:  0.021393925
p_wrong:  8.02e-7
Score:  0.822
Data Source:  BioPlex,STRINGDB
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.962535157
p_ni:  0.037464562
p_wrong:  2.81e-7
Data Source:  BioPlex
TBX20
Tbio
Family:  TF
Novelty:  0.01290983
p_int:  0.917520436
p_ni:  0.082456498
p_wrong:  0.000023065
Score:  0.859
Data Source:  BioPlex,STRINGDB
BLVRA
Tbio
Family:  Enzyme
Novelty:  0.00526407
p_int:  0.831438654
p_ni:  0.168561327
p_wrong:  1.8e-8
Score:  0.552
Data Source:  BioPlex,STRINGDB
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
p_int:  0.829799022
p_ni:  0.170200978
Score:  0.188
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.754752567
p_ni:  0.245247433
Data Source:  BioPlex
DXO
Tbio
Family:  Enzyme
Novelty:  0.08260087
Score:  0.805
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
6
91
BMI-adjusted hip circumference
2
5
7
75.9
body height
2
2
2
70.9
C-reactive protein measurement
1
1
1
44.2
BMI-adjusted waist-hip ratio
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
6
91
BMI-adjusted hip circumference
7
75.9
body height
2
70.9
C-reactive protein measurement
1
44.2
BMI-adjusted waist-hip ratio
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deoxyribonuclease 1 like 2
VGNC:13756
747007
Macaque
deoxyribonuclease 1 like 2
695708
Mouse
MGI:1913955
66705
Rat
RGD:1583566
681124
Horse
deoxyribonuclease 1 like 2
VGNC:17246
100065713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deoxyribonuclease 1 like 2
Macaque
deoxyribonuclease 1 like 2
Mouse
Rat
Horse
deoxyribonuclease 1 like 2
Publication Statistics
PubMed Score 68.13
PubMed score by year
PubTator Score 12.23
PubTator score by year
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Related Publications
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PMID
Year
Title