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Tbio
DNALI1
Axonemal dynein light intermediate polypeptide 1

Protein Summary
Description
May play a dynamic role in flagellar motility. This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296218
  • ENSP00000296218
  • ENSG00000163879

Symbol
  • P28
  • hp28
  • dJ423B22.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.67
tissue sample
0.57
gene perturbation
0.56
tissue
0.53
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.45   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.45   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
DNAI2
Tbio
Novelty:  0.02801096
Score:  0.96
Data Source:  STRINGDB
DNAH5
Tbio
Novelty:  0.01579144
Score:  0.957
Data Source:  STRINGDB
DNAI1
Tbio
Novelty:  0.01021193
Score:  0.909
Data Source:  STRINGDB
DNAAF1
Tbio
Novelty:  0.03962936
Score:  0.904
Data Source:  STRINGDB
DNAH9
Tdark
Novelty:  0.04634487
Score:  0.899
Data Source:  STRINGDB
DNAL1
Tbio
Novelty:  0.00168166
Score:  0.895
Data Source:  STRINGDB
DNAH6
Tdark
Novelty:  0.18343511
Score:  0.884
Data Source:  STRINGDB
DNAL4
Tbio
Novelty:  0.15546154
Score:  0.881
Data Source:  STRINGDB
TCTE3
Tdark
Novelty:  0.15747856
Score:  0.871
Data Source:  STRINGDB
DNAH7
Tbio
Novelty:  0.13519686
Score:  0.856
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
4
1
4
87.2
mean corpuscular hemoglobin concentration
1
1
1
81.1
red blood cell distribution width
2
1
2
75.3
monocyte count
1
1
1
71.9
intraocular pressure measurement
4
4
5
71.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
4
87.2
mean corpuscular hemoglobin concentration
1
81.1
red blood cell distribution width
2
75.3
monocyte count
1
71.9
intraocular pressure measurement
5
71.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal light intermediate chain 1
VGNC:8286
456760
Macaque
dynein axonemal light intermediate chain 1
713912
Mouse
MGI:1922813
75563
Rat
RGD:1309260
298524
Dog
dynein axonemal light intermediate chain 1
VGNC:54297
482473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal light intermediate chain 1
Macaque
dynein axonemal light intermediate chain 1
Mouse
Rat
Dog
dynein axonemal light intermediate chain 1
Publication Statistics
PubMed Score 7.45
PubMed score by year
PubTator Score 5.08
PubTator score by year
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Related Publications
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PMID
Year
Title